Extracellular potassium ions (K+) raise the intracellular concentration of free Ca2+ ([Ca2+]i) by gating voltage-dependent Ca2+ channels and stimulate aldosterone production in adrenal glomerulosa cells. The pathway leading from calcium influx to increased steroid synthesis has not been completely elucidated. In the present study we demonstrate that the reduction of pyridine nucleotides known t...

The structure of the zona glomerulosa of the rat adrenal gland stimulated by sodium restriction has been studied by light and electron microscopy. The major changes observed during the course of the experiment in stimulated glands involve cytoplasmic droplets, mitochondria, and the endoplasmic reticulum. There is a progressive decrease in the number of cytoplasmic droplets of low electron opaci...

OBJECTIVE To assess serum levels of the main factors that regulate the activation of the zona glomerulosa and aldosterone production in patients with septic shock, as well as their response to a high-dose (250 µg) adrenocorticotropic hormone (ACTH) stimulation test. SUBJECTS AND METHODS In 27 patients with septic shock, baseline levels of aldosterone, cortisol, ACTH, renin, sodium, potassium,...

the composition of the essential oils of nepeta crispa willd. and n. menthoides boiss. and buhse (lamiaceae) was investigated by means of gas chromatography (gc) and gc- mass spectrometery (ms). 1, 8-cineole was the most abundant component in oils: nepeta crispa (71%) and n. menthoides (41.1%). in the oil of n. crispa, b-pinene (5%) and d-terpineol (4.1%) were found to be the major constituents...

The production and metabolism of inositol phosphates in rat adrenal glomerulosa cells prelabeled with [3H]inositol and stimulated with angiotensin II were analyzed by high-performance anion-exchange chromatography. Exposure to angiotensin II was accompanied by a rapid and substantial decrease in the phospholipid precursor, phosphatidylinositol (PtdIns) 4,5-bisphosphate with only a slight and tr...