background and objective: sensory neurons have critical role in improvement of functional outcome of any neuroprotective strategy. the herbal medicine nepeta menthoides has been reported to have anti-apoptotic effect on axotomized spinal motoneurons. in the present study, the putative neuroprotective effect of nepeta menthoides on the axotomized dorsal root ganglion sensory neurons in neonate r...

Recently, some morphological evidences of hyperfunction of the adrenal cortex have become apparent in spontaneously hypertensive rat (SHR). The present study gave higher fluorimetric assay for either corticosterone and cortisol in SHR at the advanced stage of development of hyperten-sion. Electron microscopically, the mitochondria was closely proliferated, and the smooth surfaced endoplasmic re...

In ageing human adrenal glands there occur some morphological changes which result in alterations of their cortex endocrine function. Glucocorticoid-excreting cells in the zona glomerulosa live longer than androgen-producing cells in the zona reticularis, which undergo significant apoptosis. Therefore, in elderly humans cortisol levels are normal (significantly higher than at young age), while ...

The essential oil composition of the aerial parts of Nepeta raphanorhiza is reported for the first time. Capillary GC-FID & GC-MS analysis of the essential oil led to the identification of 16 components accounting for 97.5% of the total oil. Sesquiterpene hydrocarbons dominated the oil composition accounting for 65.3 % followed by monoterpene hydrocarbons constituting 19.5 % of the total oil co...

Non-small cell lung cancer (NSCLC) is regarded as one of the major intractable diseases, which was cured mainly by chemotherapeutics in the clinical treatment at present. But it is still a vital mission for the current medical and researchers that hunting a natural medicine which have little side effects and high-efficiency against the NSCLC on account of the shortcomings on current drugs. Nepe...

Angiotensin II (AII) regulates the secretion of aldosterone from adrenal glomerulosa cells by a calcium-dependent mechanism which involves both the uptake of calcium from the extracellular pool, and the release of calcium from a dantrolene-sensitive intracellular pool. In the present study, it was shown that AII induces the rapid (10 s) hydrolysis of phosphatidylinositol 4-phosphate and -4,5-bi...