The challenge for instrument manufacturers is to continuously improve and evolve their instrumentation to keep pace with scientific research. One field where this is evident is atmospheric aerosol research. The variety in aerosol size, shape, chemical composition, and their ability to change properties under varying atmospheric conditions creates many challenges in quantifying their impact on t...

Nephelometry has become a very reliable and convenient method for immunoassays. Recent innovations in polymer chemistry have led to the design of highly sensitive and reproducible immunoassays. Key advances include the preparation and use of particles with polystyrene cores covered by thin shells with chemically reactive groups. The shells allow a covalent binding of the immunochemicals of inte...

Nephelometry of serum before and after ultrafiltration through cellulose membranes affords a simple and rapid physical method for separately estimating pre..lipoproteins and chylomicrons in their native state. The method was rigorouslyevaluated through correlativestudies with chemical analyses, electron microscopy, and electrophoresis. Together, the data indicate that this technique, combined w...

With the recently promulgated PM2.5 mass standards, a need has appeared for continuous PM2.5 mass measuring instrumentation to complement standard filter based aerosol samplers. It is generally accepted that in most cases, the PM2.5 mass distribution and light scattering is dominated by particles with diameters in the size range 0.1–1.0μm. Early field studies indicated a reasonable correlation ...

The long-term goal is to develop and evaluate polarization sensitive instrumentation to improve the measurement and understanding of the properties of aerosols in the Marine Atmospheric Boundary Layer (MABL). Aerosol components include sea salt containing aerosols, sulfates, continental aerosols, diesel and fire smoke. Accurate characterization of the aerosols in the MABL on a real-time basis r...

We compared a rate-nephelometric method and a radial immunodiffusion (RID) assay for measurement of prealbumin (transthyretin) in 55 samples of serum from healthy children. The mean prealbumin concentration as measured by the Beckman Auto ICS nephelometer was 188 mg/L (range 128-350); the mean by RID was 221 mg/L (range 125-419). This difference was statistically significant by Student's t-test...

We have used an enzyme-linked immunoassay technique to quantify human C-reactive protein (CRP). In this assay phosphorylethanolamine is covalently linked to polystyrene wells. Serum or plasma specimens are diluted 961-fold and assayed. After Ca2+-dependent binding of CRP to the plates, the complex is reacted with peroxidase-labeled anti-CRP antibody. The response varies linearly with CRP concen...