Purpose: While contrast-enhanced MR Angiography (CEMRA) is widely used for evaluation of vascular pathology, recent nephrogenic systemic fibrosis (NSF) concerns following administration of Gadolinium based contrast agents have spurred interest in non-contrast MRA methods. Balanced steady state free precession (bSSFP) imaging [1-3] has shown great promise due to its high SNR and short scan times...

Nephrogenic systemic fibrosis (NSF) is a devastating condition associated with gadolinium (Gd3+)-based contrast agents (GBCAs) in patients with kidney disease. The release of toxic Gd3+ from GBCAs likely plays a major role in NSF pathophysiology. The cause and etiology of Gd3+ release from GBCAs is unknown. Increased Acidic Serine Aspartate Rich MEPE-associated peptides (ASARM peptides) induce ...

Introduction Magnetic resonance contrast agents, in particular the gadolinium-based agents, are very safe and lack the nephrotoxicity (when injected intravenously in the approved dose range) associated with iodinated contrast media.[1-3] Minor adverse effects occur infrequently and include nausea, taste perversion, and hives. Whereas these agents cannot be differentiated on the basis of mild ad...

Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder seen in patients with renal dysfunction, commonly precipitated by administration of gadolinium contrast. There is no consistently successful treatment, but oral steroids, topical dovonex, extracorporeal photopheresis, and plasmapheresis have been tried [http://www.icnfdr.org/ Last accessed: 1/6/2017]. Avoidance of gadolinium in such pa...

BACKGROUND Frontal fibrosing alopecia (FFA) is an acquired scarring alopecia currently considered a clinical variant of lichen planopilaris (LPP). Our purpose was to examine the clinicopathological features of FFA. In addition, we investigated the similarities and differences between FFA and LPP. METHODS Biopsies from the scalp lesions of eight patients with FFA and eight patients with LPP we...

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the histor...

Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI cont...

In the present work, a novel non-lanthanide dual-modality contrast agent, manganese tungstate (MnWO4), has been successfully constructed by a facile and versatile hydrothermal route. With the merits of a high atomic number and a well-positioned K-edge energy of tungsten, our well-prepared non-lanthanide nanoprobes provide a higher contrast efficacy than routine iodine-based agents in clinics. A...

PURPOSE To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean ...

Determination of the clinical importance of gadolinium (Gd) deposition must include the entire body. The benefit/risk assessment of only cerebral Gd deposition is not sufficient. The conclusion from the study of Schlemm et al., ‘Dentate nucleus T1 hyperintensity is not associated with gadobutrol’, suggests the authors’ confidence in administration of the macrocyclic agent gadobutrol. The statem...