Intended Audience: Pediatrics; Nephrology Outpatient Clinic; Children With Kidney Stones RENAL STONE DISEASE, or nephrolithiasis, is a major health concern associated with significant pain, morbidity, and medical cost. Recurrent nephrolithiasis can lead to chronic kidney disease, as well as increased risk of related conditions such as cardiovascular disease and fracture. The incidence of nephro...

BACKGROUND Observational studies have demonstrated an association between nephrolithiasis and hypertension. The aim of this meta-analysis was to summarize all available evidence. METHODS PubMed, EMBASE, the Cochrane Central Register of Controlled Trials databases, and the reference lists of relevant articles were searched to identify observational studies that reported study-specific risk est...

Antonio Nouvenne MD, PhD, Andrea Ticinesi MD, Tiziana Meschi MD, Department of Clinical and Experimental Medicine, University of Parma, Italy Nephrolithiasis is a disease whose prevalence is continuously rising in Western countries. The most common type is idiopathic calcium nephrolithiasis (80%), but gastrointestinal disease, especially inflammatory bowel disease (IBD), may represent a signifi...

INTRODUCTION Despite of benefits of bariatric surgery for obesity treatment, the procedure may be related to some complications. AIM Analyze studies to address the relation between nephrolithiasis and bariatric surgery. METHODS Ten papers about this theme were selected from 2005-2013 in Pubmed, describing the relation of nephrolithiasis or their risk factors with several types of bariatric ...

Nephrolithiasis is a common disorder, with a rising prevalence in the general population. Its pathogenesis is still unclear, but a role for genetics has long been recognized, especially in cases of the more common calcium nephrolithiasis. Although relatively rare, monogenic causes of hypercalciuria and nephrolithiasis do exist and their timely recognition is important from a prognostic and ther...

Familial aggregations of nephrolithiasis were already noted in the early 19th century and over the intervening years there has been gradual progression in classifying the familial forms of nephrolithiasis. To date, there are at least 10 different monogenic conditions where those affected have a predisposition to nephrolithiasis. However, all of these rare conditions probably account for less th...

The most common form of renal stone disease, calcium nephrolithiasis, is defined as the presentation of a macroscopic concrement of inorganic (calcium phosphate and/or calcium phosphate) and organic material in the renal calyces and/or pelvis, either adhered to the papillae or pelvic urothelium or not. In search of the mechanism underlying calcium nephrolithiasis, in vitro and in vivo studies a...

Nephrolithiasis is a common nephrologic disorder with complex etiology. To identify the genetic factor(s) for nephrolithiasis, we conducted a three-stage genome-wide association study (GWAS) using a total of 5,892 nephrolithiasis cases and 17,809 controls of Japanese origin. Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ra...

A positive association between nephrolithiasis and blood pressure has been suggested in previous studies. However, controversy remains, due to methodological problems in some of the previous studies and absence of prospective data. We evaluated the relationship between nephrolithiasis and the risk of hypertension in a cohort of 51,529 men followed prospectively for 8 years. Information was obta...