*Corresponding author: Pavan Malleshappa, Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences, B. G. nagara, Nagamangala Taluk, Mandya District, Karnataka State, India. E-mail: [email protected] C nephropathy refers to a disorder in which C1q deposits are seen in mesangium on immunofluorescence microscopy and mesangial electron dense deposits on el...

the incidence of diabetes mellitus (dm) is increasing rapidly and it is expected to increase by 2030. other than currently available therapeutic options, there are a lot of herbal medicines, which have been recommended for its treatment. herbal medicines have long been used for the treatment of dm because of the advantage usually having no or less side-effects. most of these plants have antioxi...

background: tocotrienols (t3) were neglected in the past; today, get attentions due to their antioxidant and none‑antioxidant activity. the objective of this study was to evaluate the effects of the daily intake of 200 mg t3 added in canola oil over 8 weeks on microalbuminuria, inflammation, and nitrosative stress in type 2 diabetic patients. methods: this study was a double‑blinded, placebo‑co...

objective: an association between high homocysteine levels and proteinuria in diabetic nephropathy has been shown. on the other hand, supplementation with folic acid lowers homocysteine concentration. we have studied the effects of folic acid supplementation on proteinuria in type 2 diabetic patients with overt proteinuria. materials and methods: forty five (29 men and 16 women) type 2 diabetic...

Adriamycin (ADR)-induced nephropathy is frequently utilized in rodent models of podocytopathy. However, the application this model mice limited to a few strains, such as BALB/c mice. The most commonly used mouse strain, C57BL/6 (B6), resistant ADR-induced nephropathy, are all strains with B6 genetic background. Reportedly, R2140C variant Prkdc gene cause susceptibility To verify hypothesis, we ...

Earlier Diabetic nephropathy was thought to be a rare complication in Type II Diabetic patients. The incidence and prevalence of nephropathy in Type II Diabetes have been under estimated in the past probably because most patients with nephropathy succumbed to cardiovascular disease, even before nephropathy could manifest clinically. The current study was done to screen Type II diabetic patients...

OBJECTIVE Glomerular mesangial expansion and podocyte loss are important early features of diabetic nephropathy, whereas tubulointerstitial injury and fibrosis are critical for progression of diabetic nephropathy to kidney failure. Therefore, we analyzed the expression of genes in glomeruli and tubulointerstitium in kidney biopsies from diabetic nephropathy patients to identify pathways that ma...

OBJECTIVE Genetic and environmental factors modulate the susceptibility to diabetic nephropathy, as initiating and/or progression factors. The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic studies for 127 candidate genes for nephropathy. RESEARCH DESIGN AND M...

  Abstract   Pseudoxanthoma elasticum is a rare, hereditary, multisystemic disease affecting   the skin, eye, and cardiovascular system. Renal involvement is uncommon.   We describe two cases of pseudoxanthoma elasticum (PXE) in two women with   distinctive skin lesions and nephrocalcinosis that renal ultrasonography showed a   characteristic pattern of dotted increased echogenicity in the cort...

abstract  background: despite the long-standing association of macrophage migration inhibitory  factor (mif) with delayed-type hypersensitivity response, the potential role  of mif in chronic allograft nephropathy is unknown. the association between upregulation of mif expression, macrophage and t cell infiltration and the severity of  chronic allograft nephropathy suggests that mif may be an i...