OBJECTIVE A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy (diabetic nephropathy). We have previously demonstrated that endothelial-mesenchymal-transition (...

Diabetic nephropathy is one of the most severe diabetic micro-angiopathies. Various factors are involved in the pathogenesis of diabetic nephropathy including, interactions between metabolic and haemodynamic factors, as well as genetic susceptibility to develop nephropathy. This study aims to evaluate the role of metabolic abnormalities and hypertension in the development of chronic renal failu...

We aimed to assess the efficacy and safety of canagliflozin in patients with type 2 diabetes nephropathy according prior history heart failure Canagliflozin Renal Events Diabetes With Established Nephropathy Clinical Evaluation (CREDENCE) trial. found that participants a at baseline (15%) were more likely be older, female, white, have atherosclerotic cardiovascular disease, use diuretics beta b...

Introduction: Hyperglycemia has generally been considered as the key initiator of kidney damage associated with diabetic nephropathy. Impaired antioxidant defense mechanism with increase oxidative stress has been proposed as the root cause underlying development of insulin resistance, beta cell dysfunction and type II DM. Methods: Present study compared the oxidant and antioxidant levels in typ...

The renin-angiotensin system, especially angiotensin II (ANG II), plays a key role in the development and progression of diabetic nephropathy. ANG 1-7 has counteracting effects on ANG II and is known to exert beneficial effects on diabetic nephropathy. We studied the mechanism of ANG 1-7-induced beneficial effects on diabetic nephropathy in db/db mice. We administered ANG 1-7 (0.5 mg·kg(-1)·day...

BACKGROUND Diabetic nephropathy (DN) is one of the life-threatening disorders characterized by persistent albuminuria, raised arterial blood pressure, a lowered glomerular filtration rate, and high risk of cardiovascular morbidity and mortality. The vascular genes ACE (Angiotensin-converting enzyme), and PPARG (peroxisome proliferator activated receptor gamma) are involved in alterations in vas...

Dysfunction of the actin cytoskeleton is a key event in the pathogenesis of diabetic nephropathy. We previously reported that certain cytoskeletal genes are upregulated in mesangial cells exposed to a high extracellular glucose concentration. One such gene, caldesmon, lies on chromosome 7q35, a region linked to nephropathy in family studies, making it a candidate susceptibility gene for diabeti...

OBJECTIVE Genetic factors have been considered to contribute to the development and progression of diabetic nephropathy. The KCNQ1 gene (potassium voltage-gated channel, KQT-like subfamily, member 1) was originally identified as a strong susceptibility gene for type 2 diabetes in two Japanese genome-wide association studies. In this study, we examined the association of single nucleotide polymo...

Hypertension is a frequent comorbidity often following the development of diabetic nephropathy among individuals with type 1 diabetes and affecting most patients with type 2 diabetes at the time of diagnosis. Multiple prospective randomized placebo-controlled trials demonstrate that tight blood pressure control among patients with diabetic nephropathy reduces the rates of macrovascular and micr...

A genome-wide association scan of type 1 diabetic patients from the GoKinD collections previously identified four novel diabetic nephropathy susceptibility loci that have subsequently been shown to be associated with diabetic nephropathy in unrelated patients with type 2 diabetes. To expand these findings, we examined whether single nucleotide polymorphisms (SNPs) at these susceptibility loci w...