Prosaposin is both a precursor of sphingolipid activator proteins and a secreted neurotrophic and myelinotrophic factor. Because peripheral nerve regeneration is impaired in diabetes mellitus, we measured prosaposin protein levels from control and streptozotocindiabetic rats by collecting endoneurial fluid secreted into a bridging tube connecting the ends of transected sciatic nerve. Prosaposin...

INTRODUCTION Recent evidence suggests that the implantation of bone marrow-derived mesenchymal stem cells improves peripheral nerve regeneration. In this study we aimed to investigate whether adipose-derived stem cells (ADSCs) can be used for peripheral nerve repair. MATERIAL AND METHODS In a rat model, nerve regeneration was evaluated across a 15 mm lesion in the sciatic nerve by using an ac...

Functional recovery after nerve lesions in the peripheral nervous system requires the accurate regeneration of axons to their original target end organs. This paper examines axonal regeneration of the primate median nerve lesioned at the wrist over nerve gap distances of up to 50 mm. Nerve gaps were bridged by either a sural nerve graft or a biodegradable collagen nerve guide tube, and recovery...

BACKGROUND [corrected] Nerve grafting is the most reliable used procedure to bridge a neural defect, but it is associated with donor site morbidity. In experimental surgery the search for an optimal nerve conduit led to the use of biological and artificial material. Nerve regeneration through epineural conduits for bridging short nerve defect was examined. METHODS Four groups including 126 Ne...

conclusions the results of this study showed that the meticulous microsurgical nerve repair, which was performed using the vein tubulization induced significantly better sciatic nerve regeneration. however, the addition of bone marrow mesenchymal stem cell to vein conduit failed to promote any significant changes in regeneration outcome. results all animals tolerated the surgical procedures and...

Neurotrauma injuries are notoriously difficult to deal with both clinically as well experimentally, the cellular and molecular events ensuing after injury complicate neuroinflammatory processes. Spinal cord further complicated by formation of scars at sites, which can provide a physical barrier repair. The lack effective clinical therapy for spinal underscores need experimental approaches gener...

The kinetics of nerve differentiation were investigated during head regeneration in Hydra. In particular the cell cycle parameters of stem cells undergoing nerve commitment were determined. Head regeneration induces extensive nerve commitment localized at the regenerating tip (G. Venugopal appearance of committed nerve precursors is followed 12 hr later by the appearance of newly differentiated...

OBJECTIVES/HYPOTHESIS Facial nerve regeneration is limited in some clinical situations: in long grafts, by aged patients, and when the delay between nerve lesion and repair is prolonged. This deficient regeneration is due to the limited number of regenerating nerve fibers, their immaturity and the unresponsiveness of Schwann cells after a long period of denervation. This study proposes to apply...