objective while the effects of folic acid are well established in prevention of neural tube defects (ntds), these diseases have a high prevalence in iran. in order to encourage folic acid supplement use in pregnancy, it is important to promote the awareness of women of childbearing age regarding folic acid importance in preventing ntds. the aim of the present study was to study the knowledge an...

how to cite this article: talebian a, soltani b, sehat m, zahedi a, noorian a, talebian m. incidence and risk factors of neural tube defects in kashan, central iran. iran j child neurol. summer 2015;9(3):50-56. abstract objective neural tube defects (ntds) are the most common congenital defects of central nervous system due to neural tube closure deficit during the third and fourth weeks of ges...

neural tube defects (ntds) are complex problem of central nervous system including brain and spinal cord. anencephaly and myelomeningocele are the two most common forms of ntds. epidemiological studies reveal that genetic and environmental factors are responsible for the development of ntds. during embryogenesis large numbers of extrinsic and intrinsic factors are responsible for the closer of ...

background: neural tube defects (ntds) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern iran. objectives: this study was conducted to determine the risk factors of neural tube defects in gorgan, north of iran. patients and methods: this hospital-based, case-control study was carried out on all ntd-affected pregnancies (n = 59) ...

OBJECTIVE To assess the role of magnetic resonance imaging (MRI) in the prenatal diagnosis of neural tube defects (NTDs). BACKGROUND NTDs comprise a heterogeneous group of congenital anomalies that derive from the failure of the neural tube to close. Advances in ultrasonography and MRI have considerably improved the diagnosis and treatment of NTDs both before and after birth. Ultrasonography ...

Neural tube defects (NTDs) are a heterogeneous group of common severe congenital anomalies which affect 1-2 infants per 1000 births. Most genetic and/or environmental factors that contribute to the pathogenesis of human NTDs are unknown. Recently, however, pathogenic mutations of VANGL1 and VANGL2 genes have been associated with some cases of human NTDs. Vangl genes encode proteins of the plana...

Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and NTDs, the biochemical mechanisms through which folic acid acts during neural tube development remain undefined. The Mthfd1l gene encodes a mitochondrial monofunctional 10-formyl-tetrahydrofolate synthetase, termed MTHFD1L....

Neural tube defects (NTDs) are among the most common complex congenital malformations observed in newborns. When the neural tube fails to close completely, severe malformations of the brain and/or spinal cord and subsequent neurologic impairment occurs. It is widely believed that nutritional, environmental and genetic interactions contribute to NTDs. It is well established that low folate level...

Neural tube defects (NTDs) are very frequent congenital abnormalities in humans. Recently, we have documented independent association of Vangl1 and Vangl2 gene mutations with NTDs. In the Looptail mouse, homozygosity (but not heterozygosity) for loss-of-function alleles at Vangl2 causes the severe NTD craniorachischisis, whereas heterozygosity for mutant variants of VANGL1 is associated with NT...