schizophrenia (scz) is a complex disorder with no clarified etiology or biological diagnosis.  symptoms of schizophrenia including positive, negative and cognitive deficits.the neurodegenrative and neurodevelopmental hypothesis are main views  about the pathophysiology of schizophrenia. neuregulin 1 is one of four proteins in the neuregulin family that act on the egfr family of receptors. nrg1 ...

Background Synaptic dysfunction is an early core feature of Alzheimer’s disease (AD), closely associated with cognitive symptoms. Neuregulin 1 (NRG1) a growth and differentiation factor key role in the development maintenance synaptic transmission. Previous reports have shown that changes cerebrospinal fluid (CSF) NRG1 concentration are status biomarker evidence AD pathology. Plasma biomarkers ...

Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan. PP1 is also targeted to RNA polymerase II (RNAPII) by NIPP1 where it can dephosphorylate RNAPII and cycle-dependent kinase 9 (CDK9). Here, we show that treatment of cells with a smal...