Ubiquitin, lysosomes and neurodegenerative diseases R. John Mayer, Lajos Laszlo, Aliya Middleton, Michael Landon, James Hope* and James Lowet Departments of Biochemistry and Pathology,? University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, U.K. and AFRUMRC Neuropathogenesis Unit,” Ogston Building, King’s Building Site, West Mains Road, Edinburgh EH9 3JF, Scotland,...

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease, amyotrophic lateral sclerosis and Huntington’s disease, are devastating diseases, with huge unmet medical needs. Although it has been estimated that the pharmaceutical industry has already spent billions of US dollars on developing a treatment for AD, the output so far has been dismal. We, like many others, hop...

Neurodegenerative disease is a progressive loss of neurons from central nervous system and has a huge impact on health care system. Various causes have been proposed of which inflammation has been suggested to be a probable key factor in the most of such conditions. The involvement of immune cells including lymphocytes in such diseased condition of the CNS supports this notion. The effective th...

Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well known and the neuronal loss well characterized. Indeed, Parkinson's disease is characterized by a loss of some but not all dopaminergic neurons, a loss of s...