Число больных, страдающих хронической болью, возрастает из года в год связи с повсеместным ростом и утяжелением травматизма, вертеброгенной патологии, нейродегенеративных заболеваний уровня развития оказания хирургической помощи. Преимущественно это касается лиц трудоспособного возраста, которые часто только результате сильных порой невыносимых болей становятся глубокими инвалидами. Цель работы...

Carbamylated erythropoietin (cEpo), which is neuroprotective but lacks hematopoietic activity, has been attracting rising concerns. However, the cellular and molecular mechanisms involved in the process of neuroprotection of cEpo are not well known. Based on several recent reports, the neuroprotective effects of cEpo are illustrated, and signaling pathways involved in the different effects of e...

This review will analyse particular criteria in the analysis of stroke diagnosis and treatment, which are pivotal for the successful translation of experimental data from the laboratory to humans.

BACKGROUND AND PURPOSE It is not known whether a combination of intraischemic and postischemic mild hypothermia provides extra neuroprotection and if so, whether the neuroprotection is persistent. METHODS Sixty-eight Sprague-Dawley rats were used. In group 1, ischemia and reperfusion were performed under normothermic (N) conditions (control, N-N). In group 2, ischemia was induced and maintain...