BACKGROUND Peripheral neurotoxicity is a dose-limiting side-effect of a number of effective chemotherapeutic agents. Neuroprotective agents may help to reduce neurotoxicity, thus allowing the intensification of cytostatic therapy in patients. MATERIALS AND METHODS In this in vitro study, using the rat pheochromocytoma cell line PC-12 neurite-outgrowth assay, the potential of amifostine to pro...

In addition to mediating several physiological functions, nitric oxide (NO) has been implicated in the cytotoxicities observed following activation of macrophages or excess stimulation of neurons by glutamate. We extend our previous observations of glutamate-stimulated, NO-mediated neurotoxicity in primary cultures of rat fetal cortical, striatal, and hippocampal neurons. Neurotoxicity elicited...

neuroprotective effect of the extract from aerial parts of scrophularia striata boiss(scrophulariaceae) was investigated against glutamate-induced neurotoxicity on cultured rat pupscerebellar granule neurons (cgns). cgns from 8 days old sprague-dawley rat were preparedand cultured. the experiments were performed after 8 days in culture. the plant was collected fromthe northeastern part (ruin re...

Neurotoxicity represents a serious complication following liver transplantation and may be evoked by various perioperative factors or develop due to toxicity of immunosuppresion. The symptoms of neurotoxicity associated with calcineurin inhibitors (CNIs) may be reversed by discontinuing or reducing the dose of CNIs; however, this may increase the risk of rejection. To address this issue, we exa...

Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...

Alzheimer's disease is accompanied by progressive, time-dependent changes of three moieties of amyloid beta. In vitro models therefore should provide same conditions for more physiologic studies. Here we observed changes in the number of fibrils over time and studied the correlation between amyloid beta moieties and neurotoxicity. Although the number of fibrils increased dramatically, the chang...

the present study was focused upon the assessment of acetyl-cholinesterase (ache) activity in the digestive gland (main metabolic center) and foot (highly innervated organ) of the green garden snail, cantareus apertus (born, 1778), exposed to different nominal dietary concentrations of pb (25 and 2500 mg pb/kg), cd (10 and 100 mg cd/kg) and their combination (25 mg pb + 10 mg cd/kg and 2500 mg ...