We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine ...

A 35-yr-old woman with rheumatoid arthritis, receiving cyclosporin A, presented with diplopia, ptosis, loss of horizontal and vertical eye movements, dysarthria, nasal regurgitation. After differential diagnosis, cyclosporin A neurotoxicity was suspected and the treatment stopped. All side-effects were reversed with the discontinuation of the drug. Central nervous system neurotoxicity with low-...