There is an error in Fig 6. Please view the correct Fig 6 here. There is an error in the second paragraph of the Results section under the subheading Validation 2: Estimating Brain-Behaviour Correlations. The correct paragraph should read: Fig 6a plots the median (ρbehav, gSNRbehav,) values for PLS analysis of every task, and both GNB and CVA analysis models. In general, IND optimization improv...

1 Association of the British Pharmaceutical Industry. Guidelines on good clinical research practice. London: ABPI, 1988. 2 Kessler DA. The regulation of investigational drugs. N Engl3JMed 1989;320:281-8. 3 Committee on Proprietary Medicinal Products, EEC. Recommended basis for the conduct of clinical trials of medicinal products in the European Community. Brussels: EEC (in press). (Document III...

Cancer and healthy cells have distinct distributions of molecular properties and thus respond differently to drugs. Cancer drugs ideally kill cancer cells while limiting harm to healthy cells. However, the inherent variance among cells in both cancer and healthy cell populations increases the difficulty of selective drug action. Here we formalize a classification framework based on the idea tha...

RACE NAME PARTY CANVASS VOTES PERCENT U. S. Representative District 1 Louie Gohmert(I) REP 129,398 89.72% Charles F. Parkes, III LIB 14,811 10.27% ----------Race Total 144,209 ---------------------------------------U. S. Representative District 2 Ted Poe(I) REP 130,020 88.61% David W. Smith LIB 16,711 11.38% ----------Race Total 146,731 ---------------------------------------U. S. Representativ...

The authors wish to clarify the methodological information for this paper. Regarding the patients included in the study, the patient samples that were from the Department of Neurology, AHEPA University Hospital (Thessaloniki, Greece) were included in the control groups. Specifically, 11 were included in the IND group, 4 in the NIND group, and 1 in the SC group. Regarding the parameters of the I...

A multidisciplinary approach offers efficiency and quality care by delegating tasks according to individuals' expertise. However, increasingly stringent regulatory requirements, albeit essential for successful conduct of clinical trials, have magnified the workload of research teams. We describe tools that have efficiently addressed regulatory requirements and facilitated the conduct of clinica...

Cancer and healthy cells have distinct distributions of molecular properties and thus respond differently to drugs. Cancer drugs ideally kill cancer cells while limiting harm to healthy cells. However, the inherent variance among cells in both cancer and healthy cell populations increases the difficulty of selective drug action. Here we propose a classification framework based on the idea that ...

It is known that studies with statistically significant results have a higher probability to be published (publication bias). Therefore, studies with no statistically significant differences (or not favoring the investigational drug) may not be found in commonly accessed databases and remain unpublished. Moreover, unpublished data may also refer to information that are not included in study rep...

Application of chemotherapy in cancerous children leads to reduction of immune system efficiency. Therefore, these children are prone to various infectious diseases. The excessive use of antibiotics can bring about antibiotic resistant strains. Hence, it is essential to investigate new therapies for this problem. On the other hand, the emergence of resistance against multiple drugs is a major p...