ObjectiveTo evaluate the evidence addressing association between use of ovarian stimulation drugs and risk breast cancer.DesignSystematic review meta-analysis.SettingNot applicable.Patient(s)Women without any previous history cancer undergoing stimulation.Intervention(s)Electronic databases were searched from 1990 until January 2020. All cohort studies reporting new incidences in infertile wome...

BACKGROUND With the large amount of pharmacological and biological knowledge available in literature, finding novel drug indications for existing drugs using in silico approaches has become increasingly feasible. Typical literature-based approaches generate new hypotheses in the form of protein-protein interactions networks by means of linking concepts based on their cooccurrences within abstra...

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection problem as to accurately predicting 1). the ranking positions of sensitive drugs and 2). the ranking orders among sensitive drugs in cancer cell lines based on ...

Little research has been done to address the huge opportunities that may exist to reposition existing approved or generic drugs for alternate uses in cancer therapy. In addition, there has been little work on strategies to reposition experimental cancer agents for testing in alternate settings that could shorten their clinical development time. Progress in each area has lagged, in part, because...

The periodic safety reporting to regulatory authorities is globally harmonized for postmarketing medicinal products by the International Conference on Harmonisation (ICH) guidelines, and is being extended for investigational drugs. To facilitate effective safety risk communication regarding investigational drugs, and to reduce duplicate periodic reporting to the US and EU by sponsors during dev...

Are Americans more individualistic and less collectivistic than members of other groups? The authors summarize plausible psychological implications of individualism-collectivism (IND-COL), meta-analyze cross-national and within-United States IND-COL differences, and review evidence for effects of IND-COL on self-concept, well-being, cognition, and relationality. European Americans were found to...

SOP 2 defines the composition and procedures of the Project Review Committee (PRC) of CESAR. The PRC works independently of the time schedule of working group meetings, and its task is to ensure a rapid and objective evaluation of trial projects proposed to CESAR via its working groups and the prompt activation of approved studies. The PRC’s decision must take into consideration the interests o...

Schizophrenia is, at once, a biological disease, a neuropsychological disorder and a dysfunction of social interactions. This presents clinicians with a series of problems with regards to therapy. In the first section of this article, some of the clinical challenges that face those attempting to develop new drugs, are summarised. Several potential pharmacological therapeutic targets that have b...

Nanotechnology has aimed to address limitations of new drug design by “repackaging” FDA approved drugs without compromising their therapeutic benefits while suppressing undesired side effects suffered patients undergoing chemotherapy. The major hurdles faced small molecular in treating cancer include hydrophobicity, rapid hepatic and renal clearance, short circulation time, off target toxicity ...