The stability of oligodeoxynucleotides to trifluoroacetic acid is studied. Pyrimidine oligonucleotides were stable in the conditions used for the removal of tbutyl groups. Oligonucleotide-3’-peptide conjugates carrying pyrimidine oligonucleotides are prepared stepwise using peptide-supports and Fmoc, t-butyl strategy. Using this strategy we have prepared an oligonucleotide-peptide conjugate con...

In pattern recognition, learning, and data mining one obtains information from information-carrying objects. This involves an objective definition of the information in a single object, the information to go from one object to another object in a pair of objects, the information to go from one object to any other object in a multiple of objects, and the shared information between objects. This ...

To illustrate the campaign to understand heavy quarkonium systems, I focus on a puzzling new state, X(3872) → ππJ/ψ. Studying the influence of open-charm channels on charmonium properties leads us to propose a new charmonium spectroscopy: additional discrete charmonium levels that can be discovered as narrow resonances of charmed and anticharmed mesons. I recall some expectations for a new spec...

The substantial increase in the prevalence of autism necessitates that practicing physicians become more familiar with the presentation of symptoms to improve early diagnoses and interventions, thus improving the prognosis for affected children. Autism is a complex neurodevelopmental disorder with a triad of core impairments in social interactions, repetitive behaviors, and communication. Clini...

A brief review is given of the present observational data in cosmology. A review of a new bimetric gravity theory with multiple light cones is presented. The physical consequences of this gravity theory for the early universe are analyzed. 1 Status of Observational Cosmology The ten most significant parameters to be determined in observational cosmology are: 1. Age of the universe: t0 2. The Hu...

The antennal lobe of insects has emerged as an excellent model for olfactory processing in the CNS. In the present review we compile data from areas where substantial progress has been made during recent years: structure-function relationships within the glomerular array, integration and blend specificity, time coding and the effects of neuroactive substances and hormones on antennal lobe proce...

Therapy of Inflammatory Bowel Disease Crohn’s disease and ulcerative colitis cause significant morbidity in the pediatric age group. The precise etiology of inflammatory bowel disease remains unknown; therefore, our therapeutic efforts continue to be directed toward controlling the symptoms. Current therapy for inflammatory bowel disease is focused on the use of steroids because of their anti-i...

Dear Colleagues, I have wanted for a long time to share with you some developments in the accreditation of family med icine (FM) residency programs. In a recent member survey, 80% of you recognized the importance of the role the CFPC plays in accrediting these programs. First, a little bit of history. Dr Victor Johnston, the first Executive Director of the CFPC, saw the need for FM training sta...

Blastomyces dermatitidis, the etiologic agent of blastomycosis, is a thermally dimorphic fungus that grows as a filamentous mold in the environment and as budding yeast in human tissue. This pathogen is endemic to North America, particularly in the states bordering the Mississippi and Ohio rivers, the Great Lakes, and the St. Lawrence Seaway. Infection with B. dermatitidis causes a broad array ...