Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effec...

The aim of this study was to investigate the role of miRNA-146a in modulating the function of vascular smooth muscle cells in a rat model of coronary heart disease. Vascular smooth muscle cells were isolated and cultured from the rat coronary heart disease model and normal rats (controls). miRNA-146a levels were measured in vascular smooth muscle cells obtained from rats with coronary heart dis...

The study aimed to observe the effects of inhaled hydrogen sulfide on smoke inhalation-induced acute lung injury in an animal model. In this study, male Sprague-Dawley (SD) rats were divided into intervention and control groups. The intervention group was divided into three subgroups: smoke group (n=6), smoke+H2S 3 h group (n=6), and smoke+H2S 6 h group (n=6). A control group (n=6) received tre...

UNLABELLED Aims/Introduction:  Advanced glycation end-products (AGE) have been implicated in the development of diabetic neuropathy. It still remains unknown, however, how AGE cause functional and structural changes of the peripheral nerve in diabetes. To explore the role of AGE in diabetic neuropathy, we examined the peripheral nerve by injecting AGE into normal Wistar rats. MATERIALS AND ME...

Articles in recent years have described two separate and distinct NF-kappaB activation pathways that result in the differential activation of p50- or p52-containing NF-kappaB complexes. Studies examining tumor-necrosis factor receptor-associated factors (TRAFs) have identified positive roles for TRAF2, TRAF5, and TRAF6, but not TRAF3, in canonical (p50-dependent) NF-kappaB activation. Conversel...

After dorsal root crush, dramatic ultrastructural differences are observed between regenerated dorsal root axonal endings that are physically blocked at a ligation neuroma and those that are allowed to form axo-glial endings among the astrocytes at the dorsal root transitional zone (DRTZ). Physically blocked axonal endings swell immensely with membranous organelles and neurofilaments (NFs) whil...

The pituitary adenylate cyclase-activating polypeptide (PACAP) is a trophic factor that promotes neuronal survival and neurite outgrowth. However, the signaling pathways and the transcriptional mechanisms involved are not completely elucidated. Our previous studies aimed at characterizing the transcriptome of PACAP-differentiated PC12 cells revealed an increase in the expression of nuclear fact...