The yeast Candida glabrata is an opportunistic pathogen of humans. C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+)). We have previously shown that a virulence-associated adhesin, encoded by EPA6, is transcriptionally induced in response to niacin limitation. Here we used transcript profiling to characterize the ...

An experiment was conducted to study the effect of adding crystalline niacin to low-protein diets on pig performance from weaning to market weight. Niacin was added at 0, 3, 9, 27, or 81 ppm to a low-protein test (LPT) diet fortified with crystalline amino acids and at 0 or 81 ppm to a positive control (PC) diet. Pens (four pigs/pen) were the experimental units with 12 and 8 pens per treatment ...

In this study the effects of supplemental crystalline niacin on sow reproduction and sow and litter performance were evaluated using 240 litters produced by 67 sows. A basal 12.80% CP corn-soybean meal-oat diet was supplemented with 0 or 33 mg of crystalline niacin/kg during gestation and lactation. The sows were grouped to equalize initial BW and parity among the two treatment groups. Each sow...

Conversion of tryptophan -to niacin in male weanling albino rats, fed high fat and high fat-high protein, was studied. High fat diet suppressed niacin biosynthesis from administered trypto phan. High protein along with high fat was found to overcome the deleterious effect of high fat on the conversion of tryptophan to niacin. Prolonged feeding of high fat decreased urinary , blood and tissue le...

A peer-verified, solid-phase extraction (SPE)/anion exchange liquid chromatographic method is presented for the determination of niacin in milk-based and soy-based infant formula. Analysis is in 3 steps: test sample digestion, extraction/cleanup, and liquid chromatography (LC). Digestion uses a standard AOAC digestion procedure that involves autoclaving at 121 degrees C for 45 min in (1 + 1) H2...

Problem statement: Glucocorticoid-induced ob gene over-expression and resulted hyperleptinemia may lead to adverse consequences especially on cardiovascular system; therefore, the present study was conducted to evaluate the effects of niacin on hyperleptinemia and ob gene overexpression due to dexamethasone administration in rats. Approach: Twenty four adult male rats divided randomly into four...

The study aimed to investigate the effect of niacin on vascular inflammatory lesions in vivo and in vitro as well as its lipid-regulating mechanism. In vivo study revealed that niacin downregulated the levels of inflammatory factors (IL-6 and TNF-α) in plasma, suppressed protein expression of CD68 and NF-κB p65 in arterial wall, and attenuated oxidative stress in guinea pigs that have been fed ...

BACKGROUND A recent study showed that niacin supplementation counteracts the obesity-induced muscle fiber switching from oxidative type I to glycolytic type II and increases the number of type I fibers in skeletal muscle of obese Zucker rats. These effects were likely mediated by the induction of key regulators of fiber transition, PGC-1α and PGC-1β, leading to muscle fiber switching and up-reg...

Background—Heme oxygenase-1 (HO-1) is a cytoprotective protein whose expression is consistently associated with therapeutic benefits in a number of pathological conditions such as atherosclerotic vascular disease and inflammation. Niacin is a pleiotropic drug that slows the progression of coronary artery disease and increases serum levels of the HO-1 enzymatic product bilirubin. This study asks...

Effects of niacin or niacinamide in diets containing either soybean meal, raw whole soybeans or whole soybeans extruded at 132 and 149 C on ruminal bacterial fermentation were examined with a dual-flow continuous culture system. In Exp. 1, soybean sources each provided 50% of total crude protein in diets comprised of 52% concentrate mix, 36% corn silage and 12% alfalfa hay (dry-matter basis). E...