Combination therapy with a statin and niacin may provide optimal therapy for patients with combined hyperlipidemia and low levels of high-density lipoprotein (HDL) cholesterol. The authors assessed the efficacy and safety of rosuvastatin monotherapy, extended-release (ER) niacin monotherapy, or rosuvastatin and ER niacin combined therapy in patients with atherogenic dyslipidemia. In a 24-week, ...

Numerous studies elucidating the probable pathway of tryptophan synthesis (1,2) and of niacin synthesis (3-9) in Neurospora have been reported. That tryptophan may serve as a precursor of niacin was first suggested by the results of nutritional studies with mammals (10, 11). This relationship has been confirmed for the rat by tracer experiments (12). A tryptophan-niacin relationship has also be...

The point of the present work was intended to think about impacts Niacin, Hedera helix  on asthma. Related parameters after enlistment asthma for 28 days and in Balb/c mice, notwithstanding research a plausibility accomplishing joined advantage niacin treatment on cytokines, total protein histological examination lung. white differential blood count BAL (Eosinophil infiltration) is Asthma marke...

Nonalcoholic fatty liver disease (NAFLD), a leading cause of liver damage, comprises a spectrum of liver abnormalities including the early fat deposition in the liver (hepatic steatosis) and advanced nonalcoholic steatohepatitis. Niacin decreases plasma triglycerides, but its effect on hepatic steatosis is elusive. To examine the effect of niacin on steatosis, rats were fed either a rodent norm...

The inhibitory mechanism of niacin, which was found in our previous study to effectively reduce acrylamide (AA) formation in both chemical models and fried potato strips, was investigated in the present study. Maillard chemical models containing the amino acid asparagine and glucose with or without niacin were closely examined by liquid chromatography/tandem mass spectrometry. Comparison of the...

Nutritional studies with mammals led to the first suggestion of a relationship between tryptophan and niacin (Krehl et al., 1945). Subsequent investigations have established tryptophan as a precursor of niacin in many organisms and have led to the identification of several of the intermediates in this biosynthetic pathway (for reviews, see Dalgliesh, 1951; Bonner and Yanofsky, 1951). Direct dem...

Catabolism of Trp and Lys produces alpha-ketoadipic acid as an intermediary metabolite. An alternate pathway of Trp turnover leads to NAD synthesis. We hypothesized that excess Lys might improve the conversion of Trp to niacin by causing a buildup of alpha-ketoadipic acid, thereby endproduct inhibiting the main Trp catabolic pathway and resulting in more niacin synthesis from Trp. Six bioassays...

Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis. In this report, using HepG2 cells, we have examined the effect of niacin on the mRNA expression and microsomal activity of diacylglycerol acyltransferase 1 and 2 (DGAT1 and DGAT2), the last committed but distinctly different enzymes for triglyceride ...

BACKGROUND AND PURPOSE Sustained release niacin effectively lowers serum cholesterol, LDL and triglycerides, while raising HDL. However, 75% of patients experience cutaneous warmth and itching known as flush, leading to discontinuation. Acetylsalicylic acid (aspirin) reduces this flush only by about 30%, presumably through decreasing prostaglandin D2 (PGD2). We investigated whether niacin-induc...

Niacin has long been prescribed for the treatment of various cardiovascular conditions, particularly the hyperlipidemias. It has been proven effective at lowering VLDL, LDL, total cholesterol and triglyceride levels while raising HDL levels. The side effects of niacin which may occur at the dosages often required for therapeutic efficacy, ranging from flushing and pruritus to hepatoxicity and i...