An occupational hygiene survey was made in 38 nickel plating shops in Finland and exposure to nickel was studied by means of biological measurements and, in three shops, by using air measurements. The average after-shift urinary nickel concentration of 163 workers was 0.16 mumol l.-1 (range 0.001-4.99 mumol l.-1). After the 1-5 week vacation the urinary nickel concentration was higher than the ...

A nickel sensitivity patch test was applied to 700 child dental patients, aged 5-12 years,from the Dental Clinic at the University of Western Ontario and nearby pediatric dental offices. Approximately one-half the children were known to have nickel-containing dental appliances. From a case history obtained from the paten ts, the history of the wearing of pierced earrings and other jewelry was a...

Nickel is an essential metal for Helicobacter pylori, as it is the co-factor of two enzymes crucial for colonization, urease and hydrogenase. Nickel is taken up by specific transporters and its intracellular homeostasis depends on nickel-binding proteins to avoid toxicity. Nickel trafficking is controlled by the Ni(II)-dependent transcriptional regulator NikR. In contrast to other NikR proteins...

Bacteria have evolved a number of tightly controlled import and export systems to maintain intracellular levels of the essential but potentially toxic metal nickel. Nickel homeostasis systems include the dedicated nickel uptake system nik found in Escherichia coli, a member of the ABC family of transporters, that involves a periplasmic nickel-binding protein, NikA. This is the initial nickel re...

Nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori. Indeed, H. pylori possesses two nickel-enzymes that are essential for in vivo colonization, [NiFe] hydrogenase and urease, an abundant virulence factor that contains 24 nickel ions per active complex. Because of these two enzymes, survival of H. pylori relies on an important supply of nickel, implying a tight ...

Although nickel exposure results in allergic reactions, respiratory conditions, and cancer in humans and rodents, the ramifications of excess nickel in the environment for animal and human health remain largely undescribed. Nickel and other cationic metals travel through waterways and bind to soils and sediments. To evaluate the potential toxic effects of nickel at environmental contaminant lev...

Release of nickel from nickel or nickel-plated metals, is often responsible for allergic contact dermatitis. However, the effect of nickel-bearing stainless steels is not weil known. ln this paper AISI 304, 316 and 430 type stainless steels, as weil as nickel and nickel-plated materials, are investigated. Three tests were carried out: electrochemical tests and leaching experiments in sodium chl...

A simple and convenient approach denoted as gel-deposition-precipitation (G-D-P) for the preparation of core-shell-like silica@nickel species nanoparticles was studied systematically. Core-shell-like silica@nickel species nanoparticles consisted of a Si-rich core and a Ni-rich shell. The G-D-P process included two steps: one was the deposition-precipitation of nickel over the gelled colloidal s...

Using human and rodent cells in vitro, we characterized a hypoxia-inducible signaling pathway as one of the pathways affected by carcinogenic nickel compounds. Acute exposure to nickel activates hypoxia-inducible transcription factor-1 (HIF-1), which strongly induces hypoxia-inducible genes, including the recently discovered tumor marker Cap43. This gene has been cloned based on its nickel indu...

Nickel is the most common cause of allergic contact dermatitis in females. The dermatitis can be maintained both by direct contact and by ingestion of nickel. In 9 out of 17 patients suffering from dermatitis, a diet with a low nickel content has improved their condition. Eleven patients with chronic nickel hand dermatitis were given a daily dosage of 200 to 400 mg of tetraethylthiuramdisulfide...