Hirshfeld surface analysis, a suitable tool for investigating intermolecular interactions, has been widely used in crystallography recent years. A breakdown of related fingerprint graphics is presented as color chart, allowing quantitative analysis interaction types. In this study, the interactions di¬aqua¬bis¬(4-cyano-benzoato-?O)bis¬(nicotinamide-?N1)cobalt(II) (I), di¬aqua¬bis¬(4-cyano¬benzo...

Deficits in the mineral Zn are responsible for a sizable proportion of world’s disease burden and child mortality. With increasing success rate biofortification major crops, development genotype with enhanced bioavailability will be an efficient sustainable solution to nutrient deficiency-related problems. Due complex chemistry human system, absorption from cereals is lower. This complexity all...

OBJECTIVES Spinal cord injury is a devastating complication after aortic surgery. The aim of the present study is to examine the effects of ischemic preconditioning (IPC) and nicotinamide containing perfusate in transient aortic occlusion in the rat. METHODS Thirty-two male Spraque-Dawley rats under general anesthesia were randomly assigned to four groups (n=8 in each group). The infrarenal a...

Nicotinamide is amide form of vitamin B3, participate in oxidation-reduction reaction, and it plays an important role in the maintenance of normal life activities in cells; it has broad application prospects in the treatment of heart blood-vessel disease, respiratory disease, type 1 diabetes and inflammatory autoimmune diseases. Thus the present study aimed to identify whether the nicotinamide ...

BACKGROUND Exposure to the chemotherapeutic alkylating agent thiotepa during brain development leads to neurological complications arising from neurodegeneration and irreversible damage to the developing central nerve system (CNS). Administration of single dose of thiotepa in 7-d postnatal (P7) rat triggers activation of apoptotic cascade and widespread neuronal death. The present study was aim...

The most common adverse effects that are related to all-trans retinoic acid (atRA) treatment are irritation and dryness of the skin. atRA therapy is reported to impair barrier function as achieved by trans-epidermal water loss (TEWL). Treatment with nicotinamide prior to initiation of atRA therapy provides additional barrier protection and thus reduces susceptibility of retinoic acid. Our previ...

Poly (ADP-ribose) synthase or polymerase (PARS and PARP, respectively) is a cytotoxic enzyme which causes cellular damage. Nicotinamide, a compound of vitamin B complex, has been reported to exert an inhibitory effect on PARS or PARP. The present study tests the effects of nicotinamide on acute lung injury and associated alterations following ischaemia/reperfusion (I/R) of the isolated perfused...