Nicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3). Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan. Nicotinamide is also commercially available in vitamin supplements and in a range of cosmetic, hair, and skin preparations. Nicotinamide is the prima...

Study of interaction between nicotinamide and human serum albumin using spectroscopic techniques molecular docking simulation

cADP-ribose (cADPR) induces the release of Ca(2+) from the intracellular stores of coronary artery smooth muscle cells. However, little is known about the role of cADPR-mediated intracellular Ca(2+) release in the control of vascular tone. The present study examined the effects of nicotinamide, a specific inhibitor of ADP-ribosylcyclase, on the vascular tone of bovine coronary arteries. A bovin...

The feasibility and early toxicity of radiotherapy with carbogen breathing and nicotinamide was tested in 74 head and neck cancer patients. Forty patients with laryngeal and hypopharyngeal tumors were treated with an accelerated schedule combined with carbogen alone (16) or with carbogen and nicotinamide (24). Thirty-four patients with far advanced unresectable tumors of the oral cavity and oro...

Sirtuins are protein deacylases regulating metabolism and aging processes, and the seven human isoforms are considered attractive therapeutic targets. Sirtuins transfer acyl groups from lysine sidechains to ADP-ribose, formed from the cosubstrate NAD(+) by release of nicotinamide, which in turn is assumed to be a general Sirtuin inhibitor. Studies on Sirtuin regulation have been hampered, howev...

Objective: To compare the efficacy of topical 5% Nicotinamide gel versus 2% Clindamycin in patients with mild to moderate acne.
 Study Design: Comparative cross-sectional study.
 Place and Duration Study: Department Dermatology, Combined Military Hospital, Quetta Pakistan, from Jan Jun 2019.
 Methodology: Patients acne were enrolled study. A total 372 randomly equally divided int...

We have previously reported that a single injection of nicotinamide into mice leads to over a lo-fold increase in liver diphosphopyridine nucleotide (DPN) (1). The maximal increase in DPN concentration occurred from 8 to 12 hours after administration of the nicotinamide; this increase is followed by a pronounced decrease, and after 24 hours the DPN level is essentially the same as that of the u...

The alkaline comet assay was used to measure both tumor hypoxic fraction and DNA strand break rejoining kinetics in individual cells from tumors and tissues of C3H/HeN mice exposed to ionizing radiation and nicotinamide. The percentage of hypoxic cells in SCCVII marine squamous cell carcinoma decreased from 18.4 to 4.4% in mice injected with a clinically relevant dose of 200 mg/kg nicotinamide ...

SUR2A is an ATP-binding protein that serves as a regulatory subunit of cardioprotective ATP-sensitive K(+) (K(ATP) ) channels. Based on signalling pathway regulating SUR2A expression and SUR2A role in regulating numbers of fully assembled K(ATP) channels, we have suggested that nicotinamide-rich diet could improve physical endurance by stimulating SUR2A expression. We have found that mice on ni...