Validation of the ethnotherapeutic claim of Clerodendrum infortunatum L. was investigated to evaluate its wound-healing potency in experimental rats. For topical application, 4% (w/w) ointment cream bases of petroleum ether, chloroform and ethanol extracts were prepared and assessed for their effect on excision, incision and dead space wound models. Significant wound healing was observed in ani...

No fully effective treatment has been developed since the discovery of Chagas' disease by Carlos Chagas in 1909. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effectiveness in the acute phase but with various adverse side effects, more studies are needed to characterize the susceptibility of T. cruzi to new drugs. Many natural and/or synthetic substance...

A study was carried out to determine the antibiotic resistance in bacteria isolated from Artemia nauplii and the efficiency of formaldehyde to control the bacteria associated with Artemia nauplii. The total aerobic heterotrophic bacteria of Artemia nauplii was determined on seawater nutrient agar and TCBS agar, and ranged from 3.8=10 to 8.1=10 and 9.4=10 to 4.3=10 colony Ž . forming units CFU p...

Gallic acid (GA), rutin(R), quercitin (Q), ellagic acid (EA) and sitosterol(S) isolated from the methanolic extract of the leaves of Tectona grandis were formulated as 0.2 % ointment in emulsifying base and were evaluated for their wound healing activity. The animals were divided into eight groups of six animals each. Groups 1 used as control, group 2 used as a standard i.e. nitrofurazone ointm...

OBJECTIVES Grapefruit-seed extract (GSE) Citricidal has, in recent reports, been reported to be successful in combating a variety of common infectious agents. In our study, drops of concentrated grapefruit-seed extract were tested for antibacterial properties against a number of gram-positive and gram-negative organisms. DESIGN Sixty-seven (67) distinct biotypes were tested for their suscepti...

The carcinogenicity of 35 compounds was evaluated in young female Sprague-Dawley rats 9 months after the oral feeding of 10 doses at the maximally tolerated level. The following compounds were definitely active in causing breast cancer: 2-anthramine, 2,7-fluorenediamine, benzidine, Af-6-(3,4-benzocoumarinyl) ace tumide, [<*-(2-methylhydrazino)toIuoyl]urea, and 7,12-dimethylbenz[a]anthracene, th...

Nitroheterocyclic and nitroaromatic compounds constitute an enormous range of chemicals whose potent biological activity has significant human health and environmental implications. The biological activity of nitro-substituted compounds is derived from reductive metabolism of the nitro moiety, a process catalyzed by a variety of nitroreductase activities. Resistance of bacteria to nitro-substit...