Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglyc...

This study was designed to evaluate the effects of nitroglycerin and phenylephrine-induced arterial hypertension on regional myocardial blood flow in awake dogs with acute occlusion of the left circumflex coronary artery. Myocardial blood flow to four transmural layers from epicardium to endocardium was estimated with 7-9 micron radionuclide labeled microspheres in 1) the nonischemic myocardium...

BACKGROUND Sublingual nitroglycerin increases exercise duration in patients with stable angina. Brief results from this study were published previously in German. Here, we more fully describe the study methodology, patient characteristics, and detailed results. METHODS This double-blind, crossover study enrolled 51 patients with stable angina. Patients were randomized to 1 of 5 treatment sequ...

CONTEXT Nitroglycerin stimulates bone formation and inhibits bone resorption, is inexpensive, and is widely available. Its effects on bone density, bone structure, and bone strength are unknown. OBJECTIVES To determine if nitroglycerin increases lumbar spine bone mineral density (BMD) and to evaluate changes in hip BMD, bone geometry, and density at the radius and tibia, and markers of bone t...

an in vitro study on the role of intracellular calcium ions in healing of excisional wound in rabbit was undertaken. we employed two drugs namely, glibenclamide and nitroglycerin that are topically applied in vivo to modulate the activity of intracellular calcium. our model consisted of a 15 ´ 15 mm excisional wound. seven groups of new zealand rabbits were used. the first three groups served a...

background rhinoplasty is one of the most common surgeries of the plastic surgery and as well as ear, throat and nose. intra-operative bleeding during surgery is one of the most important factors that may impair the surgeon’s job. providing a clean blood-free surgical filed makes the operation faster, easier and with a better quality. one way to achieve this goal is to induce hypotension. this ...

lingual long-acting nitrates more prolonged than that achieved by nitroglycerin. It is likely that the duration of action of the sublingual nitrates is not as long as would be ideal, merely more prolonged than that achieved by nitroglycerin: a 1-21/2 hour duration of action seems most likely. Evidence that oral "long-acting nitrates" have a prolonged duration of action is, we agree, lacking. Al...

Nitrates have been a major part of the internist's pharmacopoeia for more than 100 years, predominantly for the relief of anginal symptoms. The effects of nitroglycerin on the eye and specifically on intraocular pressure has been investigated with diverse results. However, nitroglycerin may also serve to protect retinal ganglion cells against glutamate mediated toxicity--a form of cell death th...

s related to the PhD thesis I. Párdutz Á, Vécsei L, Schoenen J Systemic nitroglycerin administration increases nitric oxide synthase-immunoreactive cells in rat spinal trigeminal nucleus: towards a better understanding of the possible role of nitric oxide in migraine? Headache World, London, UK, 2000, Cephalalgia 20: 281. II. Párdutz Á,Vécsei L, Schoenen J Systemic nitroglycerin administration ...

Histopathologic-electrographic studies of ventriculography depicted nitroglycerin responsive and unresponsive asynergic areas were performed in 25 patients. Of 29 areas, 12 improved with nitroglycerin, showing less than 10% muscle loss. Seventeen unimproved zones demonstrated significant fibrosis. Epicardial electrograms showed R waves in eight of nine improved zones. Of 11 unimproved zones, ei...