Safavi et al. (1) examined whether hydralazine, nitroglycerin or nifedipine effectively attenuates the hemodynamic response to laryngoscopy and tracheal intubation in severe preeclamptic women undergoing cesarean delivery under general anesthesia. They found that continuous intravenous (IV) infusion of nitroglycerin was more effective in attenuating the pressor response than IV hydralazine 5-10...

Experiments focused on evaluating the ability of three aquatic plant species (sweet flag, common reed, and broadleaf cattail) to decontaminate industrial wastewater effluents from a nitroglycerin and nitroglycol production factory were carried out in the framework of this study. Toxicity of a nitrate-rich wastewater toward the studied plant species was determined by measurement of plant biomass...

Intravenous nitroglycerin (GTN) has been used as an anti-ischemic agent for the therapy of unstable and post-infarction angina. Nitric oxide (NO) and S-nitrosothiols constitute the biologically active species formed via nitroglycerin bioactivation. Increased levels of reactive oxygen species can diminish the therapeutic action of organic nitrates by scavenging donated NO and oxidizing tissue th...

BACKGROUND The ex utero intrapartum treatment (EXIT) procedure is a technique designed to establish an airway at the time of delivery in fetuses at risk of airway obstruction and requires maintenance of uterine relaxation to continue placental perfusion and prevent placental separation. We describe the use of intravenous nitroglycerin to maintain uterine relaxation during the EXIT procedure. ...

Since the dimensions of the ventricles are related to both myocardial tension and myocardial oxygen consumption (MVO2), the effects of nitroglycerin on the left ventricular volumes and left ventricular haemodynamics were studied in patients with ischaemic heart disease. The ventricular volumes were estimated using the constant infusion technique (indocyanine green) of Shaffer (1964). Sublingual...

The results of prior studies indicate that nitroglycerin stimulates prostacyclin release by cultured endothelium and by the coronary vasculature in vivo. However, the accuracy of these findings in coronary vasculature relies on plasma samples obtained from the circulation via cardiac catheters, a procedure we have shown to stimulate prostacyclin release, thereby confounding'interpretation of dr...

were studied. Observations were made upon changes in heart rate, myocardial oxygen consumption, systolic vigor, and the electrocardiograms. Data are presented showing the effects of nitroglycerin and adrenergic agents when given separately and in combination. Results indicate that in dogs, nitroglycerin produces no antiadrenergic effects on the myocardium. The suggestion is made that the T wtav...

Nesiritide is an effective agent for the treatment of decompensated CHF. However, the VMAC trial shows that the agent's efficacy and safety are actually more similar than dissimilar to those of nitroglycerin. Indeed, objective reviews have placed nesiritide as a second-line agent behind current standard drug therapy. Finally, nesiritide is approximately 40 times the purchase price of standard a...

out coronary disease. Cathet Cardiovasc Diagn 3: 47, 1977 14. Schnaar RL, Sparks HV: Response of large and small coronary arteries to nitroglycerin, NaNO^, and adenosine. Am J Physiol 22: 223. 1972 15. Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM: Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. Circ Res 44: 176, 19...

There is evidence that platelet activation in the coronary circulation may be important in the pathogenesis of myocardial ischemia. Since organic nitrate vasodilators are commonly used in coronary artery disease, we have studied the in vitro effects of these drugs on platelet function. Nitroglycerin, isosorbide dinitrate, and their biotransformation product, inorganic nitrite, inhibited platele...