in this paper, a comprehensive model is proposed to design a network for multi-period, multi-echelon, and multi-product inventory controlled the supply chain. various marketing strategies and guerrilla marketing approaches are considered in the design process under the static competition condition. the goal of the proposed model is to efficiently respond to the customers’ demands in the presenc...

Lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. Although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (HIV-1) and ...

We analyze the influence of noise in transverse hexagonal patterns in nonlinear Kerr cavities. The near-field fluctuations are determined by the neutrally stable Goldstone modes associated to translational invariance and by the weakly damped soft modes. However, these modes do not contribute to the far-field intensity fluctuations that are dominated by damped perturbations with the same wave ve...

abstract: in this paper, optimization of boeing 747 wing has been accomplished for cruise condition (mach number=0.85, flight altitude=35000 ft), where an optimal wing shape is proposed. objective functions are minimization of wing weight and drag force that as well as confining design parameters, two functional constrains are applied. the first functional constrain is fuel tank volume in the a...

A novel approach is presented in this article for obtaining inverse mapping of thermodynamically Pareto-optimized ideal turbojet engines using group method of data handling (GMDH)-type neural networks and evolutionary algorithms (EAs). EAs are used in two different aspects. Firstly, multi-objective EAs (non–dominated sorting genetic algorithm-II) with a new diversity preserving mechanism are us...

Many blood-feeding arthropods are known vectors of viruses that are a source of unprecedented global health concern. Mosquitoes are an integral part of these arthropod vectors. Advancements in next-generation sequencing and bioinformatics has expanded our knowledge on the richness of viruses harbored by arthropods. In the present study, we applied a metagenomic approach to determine the interco...

This paper considers a multi-period, multi-product inventory-routing problem in a two-level supply chain consisting of a distributor and a set of customers. This problem is modeled with the aim of minimizing bi-objectives, namely the total system cost (including startup, distribution and maintenance costs) and risk-based transportation. Products are delivered to customers by some heterogeneous ...