The response of enzymatic (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPX and glutathione reductase, GR) and non-enzymatic responses (glutathione, GSH, oxidized glutathione, GSSG and GSH/GSSG) against acute Cu toxicity (2-90μg/mL for 48h) in different tissues of Lymnaea stagnalis were measured. Incubation conditions for enzymatic activity measurements were optimized for L...

A fine balance in reactive oxygen species (ROS) production and removal is of utmost importance for homeostasis of all cells and especially in highly proliferating cells that encounter increased ROS production due to enhanced metabolism. Consequently, increased production of these highly reactive molecules requires coupling with increased antioxidant defense production within cells. This couplin...

Free radical-mediated oxidative stress has been implicated in the etiopathogenesis of several autoimmune disorders. Hypothyroidism in humans is widely believed to impair health. The biochemical factors mediating decline in health, however, are poorly elucidated. Pathological consequences of hypothyroidism point to a high potential for antioxidant imbalance. The study population consisted of 60 ...

Cisplatin (CP) is a potent anti-cancer drug widely used against solid tumors. However, it exhibits pronounced adverse effects including hepatotoxicity. Several strategies were attempted to prevent CP hepatotoxicity but were not found suitable for therapeutic application. Nigella sativa has been shown to prevent/reduce the progression of certain type of cardiovascular, kidney and liver diseases....

The effect of taurine treatment on antioxidant defense in liver and brain tissues of old rats was investigated. Endogenous malondialdehyde (MDA) and diene conjugate (DC), ascorbic acid (AA)- and NADPH-induced lipid peroxide levels as well as non-enzymatic (glutathione--GSH, vitamin E and vitamin C) and enzymatic antioxidants (superoxide dismutase, glutathione peroxidase and glutathione transfer...

Drought is a major abiotic stress forced by the changing climate that affects plant production and soil structure functions. A study was conducted to explore impacts of ascorbic acid (AsA) ?-tocopherol (?-toc) on agro-physiological attributes antioxidant enzymes chickpea grown in water deficit regions. The results analysis showed electrical conductivity (EC) pH were decreased from 521 mS/m 7.08...

Body has defense mechanisms against oxidants in the form of both enzymatic and non enzymatic antioxidants. Oxidants have both physiological and pathological role in female reproduction. Oxidative stress causes damage to the ovaries, oogonia and ovulation as well as in implantation procedures. A study was undertaken to evaluate the polycystic ovary syndrome (PCOS) induced stress in ovarian and u...

BACKGROUND The effect of α-tocopherol or simvastatin treatment on antioxidant defense in liver of old rats was investigated. METHODS Endogenous thiobarbituric acid reactive substances (TBARS) and total nitrite/nitrate (NO(2)/NO(3)) levels as well as non-enzymatic glutathione (GSH) and enzymatic antioxidants [glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (...

The number of reports on the effects of diabetes is still increasing because the diabetes is one of the major disease of industrialized and non-industrialized societies. Because at least 30 million people throughout the world suffer from diabetes, there is currently great interest in the potential contribution of increased oxidative stress to the pathogenesis of diabetes as well as its complica...

Deltamethrin is -cyano pyrethroid insecticide used extensively in pest control. Although initially thought to be least toxic, a number of recent reports showed its toxicity in mammalian and non-mammalian laboratory and wildlife animal species. Lycopene is the pigment that gives tomatoes their red color and is one of four main carotenoids normally found in human blood and tissue. The present stu...