OBJECTIVE To investigate the association between use of non-steroidal anti-inflammatory drugs and serious, acute non-infectious liver injury. DESIGN Retrospective cohort study, cross over design. SETTING Health records from provincial database in Saskatchewan, Canada, 1982-6. SUBJECTS 228,392 adults who contributed 645,456 person years. All were either using or had used non-steroidal anti...

purpose: to report a case of severe macular edema following the taking of fingolimod in multiple sclerosis. case report: a 34-year-old woman with a long history of relapsing-remitting multiple sclerosis presented complaining of blurred vision in the left eye that started 1 week before the presentation. she had been taking fingolimod for 4 months. she was not diabetic and had no history of uveit...

VERY year 20 million prescriptions are written for non-steroidal anti-inflammatory drugs in Great Britain (about 5% of all National Health Service prescriptions).' A recent study has shown that for 85%o of patients on long term non-steroidal anti-inflammatory drugs the treatment was initiated by their general practitioner.2 However, reports from the Committee on Safety of Medicines claim that t...

Although non-steroidal anti-inflammatory drugs (NSAIDs) and opioid compounds are widely used in the releif of pain, they are not always useful due to their side effects. It seems necessary to search for newer analgesic compounds. Therefore, we decided to study the analgesic effects of this plant. For extraction, percolation method was used and different weights of dried extract were dissolved i...