Abstract Nonalcoholic fatty liver disease (NAFLD) is a systemic, dynamic, heterogeneous, and multiaxis entity, the pathogenesis of which still uncertain. The gut–liver axis regulated stabilized by complex network encompassing metabolic, immune, neuroendocrine cross-talk between gut, microbiota, liver. Changes in affect metabolism lipids carbohydrates hepatocytes, they impact balance inflammator...

background: recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in wistar rats. it provided liver protection against chemical, cholestatic, and alcohol injury. resveratrol can improve glucose metabolism an...

Nonalcoholic fatty liver disease (NAFLD) is diagnosed when there is an accumulation of fat in the liver (>5%) in the absence of alcohol abuse or other chronic liver diseases (CLD) [1]. It is the most frequent cause of elevated liver enzyme levels worldwide [2]. NAFLD can progress to nonalcoholic steatohepatitis (NASH) with liver inflammation, fibrosis, cirrhosis or finally to hepatocellular can...

Nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease, yet whether identification of NAFLD in asymptomatic individuals is helpful over established risk factors remains unknown. A total of 37,799 asymptomatic adults aged 20 years or older who underwent comprehensive health check-up examination, including abdominal and carotid artery duplex ultrasonography (US) were i...

Background: Disturbance of the gut microbiota may play a critical role in progression nonalcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD). Changes were analyzed rat HFD-induced NAFLD model following treatment with Qinghua Fang (QHF), Chinese herbal formula currently used clinical practice traditional medicine.