Transient tritanopia is a cone-cone post-receptoral interaction between short-wavelength (S) cones and medium (M) and long (L) wavelength cones. Blue cone monochromats have rods and S cones of normal sensitivity but lack functional M/L cones. All blue cone monochromats tested (n = 8) show significant amounts of transient tritanopia mediated by rods. Attempts to find a similar rod-S cone interac...

PURPOSE To describe the electrophysiological, histologic, and hereditary features of a naturally occurring rat model of cone function loss. METHODS Dark- and light-adapted electroretinograms (ERGs) were used to evaluate retinal function. The thickness and architecture of the retina were observed by light microscopy. The cone density was investigated by wholemount immunocytochemistry. The inhe...

Mediated by guanylate cyclase-activating proteins (GCAPs), cytoplasmic Ca2+ levels regulate the activity of photoreceptor guanylate cyclase (GC) and the synthesis of cGMP, the internal transmitter of phototransduction. When GCAP1 is expressed in transgenic mice on a GCAP null background, it restores the wild-type flash responses in rod photoreceptors. In this communication, we explored the role...

Huang and Zhang 1 generalized the notion of metric space by replacing the set of real numbers by ordered Banach space, deffined a cone metric space, and established some fixed point theorems for contractive type mappings in a normal cone metric space. Subsequently, several other authors 2–5 studied the existence of common fixed point of mappings satisfying a contractive type condition in normal...

We study the problem of testing a simple null hypothesis on multivariate normal mean vector against smooth or piecewise smooth cone alternatives. We show that the mixture weights of the  distribution of the likelihood ratio test can be characterized as mixed volumes of the cone and its dual. The weights can be calculated by integration involving the second fundamental form on the boundary of t...