schizophrenia (scz) is a complex disorder with no clarified etiology or biological diagnosis.  symptoms of schizophrenia including positive, negative and cognitive deficits.the neurodegenrative and neurodevelopmental hypothesis are main views  about the pathophysiology of schizophrenia. neuregulin 1 is one of four proteins in the neuregulin family that act on the egfr family of receptors. nrg1 ...

objective: neuregulin1 (nrg1) gene is among the most promising candidate genes for schizophrenia. this gene is located on 8p22-p12, a region with a reported linkage to schizophrenia. several studies have reported an association between schizophrenia and the 5′ end polymorphisms in this gene. however, some studies have failed to confirm the role of nrg1 gene in the pathogenesis of schizophrenia....

The Neuregulin is a member of the epidermal growth factors (EGF) family of receptor kinases, was originally identified as the product of the transforming gene derived from chemically induced rat neuroblastoms. A variety of different protein isoforms are produced from single Neuregulin gene. Four distinct vertebrate gene encode Neuregulin, prosaically named NRG1, NRG2, NRG3, and NRG4. Most of bi...

Schizophrenia is a severe neuropsychiatric disorder with symptoms such as hallucination, delusion and mental disorder. It is a complex disorder, in which genetic components play a crucial role in its pathogenesis. Among candidate genes for schizophrenia, Neuregulin 1 (NRG1) gene is the most important gene,  association of which with the illness has been confirmed in several studies. Single nucl...

schizophrenia is a severe neuropsychiatric disorder with symptoms such as hallucination, delusion and mental disorder. it is a complex disorder, in which genetic components play a crucial role in its pathogenesis. among candidate genes for schizophrenia, neuregulin 1 (nrg1) gene is the most important gene,  association of which with the illness has been confirmed in several studies. single nucl...

the neuregulin is a member of the epidermal growth factors (egf) family of receptor kinases, was originally identified as the product of the transforming gene derived from chemically induced rat neuroblastoms. a variety of different protein isoforms are produced from single neuregulin gene. four distinct vertebrate gene encode neuregulin, prosaically named nrg1, nrg2, nrg3, and nrg4. most of bi...

euregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, nd genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at he 5= end of the NRG1 gene, in many but not all case-control and family studies. NRG1 is a pleiotropic growth factor, important in ervous sy...

Schizophrenia is a chronic psychiatric disorder with a lifetime prevalence of about 1% in the general population. Recent studies have shown that Neuregulin-1 (Nrg1) is a candidate gene for schizophrenia. At least 15 alternative splicing of NRG1 isoforms all contain an extracellular epidermal growth factor (EGF)-like domain, which is sufficient for Nrg1 biological activity including the formatio...

Schizophrenia is a severe mental illness that affects approximately 1% of the population worldwide. Genetic factors play a major role in the etiology of schizophrenia, with an estimated heritability of around 80%. Genetic variation in Neuregulin 1 (NRG1) has been repeatedly linked to the disorder in multiple human populations. In particular, more than 80 single nucleotide polymorphisms localize...

objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the ‎pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 ‎is associated with schizophrenia and its negative symptoms in an iranian population.‎ method: rs2439272 was genotype...