نتایج جستجو برای: nsclc

تعداد نتایج: 17801  

2012
Patrick T. Hennessey Tiffany Sanford Ashish Choudhary Wojciech W. Mydlarz David Brown Alex Tamas Adai Michael F. Ochs Steven A. Ahrendt Elizabeth Mambo Joseph A. Califano

Non small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality world-wide and the majority of cases are diagnosed at late stages of disease. There is currently no cost-effective screening test for NSCLC, and the development of such a test is a public health imperative. Recent studies have suggested that chest computed tomography screening of patients at high risk of lung ca...

2009
Charu Aggarwal Hossein Borghaei

Lung cancer is the leading cause of mortality in the United States. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. Most NSCLC patients present with loco-regionally advanced or metastatic disease where response rates are low and median overall survival approximates 8 to 10 months. Chemotherapy is the mainstay of treatment for NSCLC patients with metastatic...

Journal: :Cancer research 2003
Amy S Clark Kip A West Peter M Blumberg Phillip A Dennis

Drugs that target protein kinase C (PKC) are now being evaluated in patients with non-small cell lung cancer (NSCLC), but the role of PKC in NSCLC cells remains unclear. We report here that NSCLC cell lines show enhanced phosphorylation and altered expression of specific PKC isoforms compared with normal lung epithelial cells. PKC inhibition variably increased apoptosis, with rottlerin, a PKCde...

2016
Shuiliang Wang Ling Zhu Weimin Zuo Zhiyong Zeng Lianghu Huang Fengjin Lin Rong Lin Jin Wang Jun Lu Qinghua Wang Lingjing Lin Huiyue Dong Weizhen Wu Kai Zheng Jinquan Cai Shunliang Yang Yujie Ma Shixin Ye Wei Liu Yinghao Yu Jianming Tan Bolin Liu

Elevated expression of Survivin correlates with poor prognosis, tumor recurrence, and drug resistance in various human cancers, including non-small cell lung cancer (NSCLC). The underlying mechanism of Survivin upregulation in cancer cells remains elusive. To date, no Survivin-targeted therapy has been approved for cancer treatment. Here, we explored the molecular basis resulting in Survivin ov...

Journal: :Molecular medicine reports 2015
Yumin Wang Gang Xu Wei Chen Qinshi Pan Kate Huang Jingye Pan Wenhui Zhang Jie Chen

Long‑chain non‑coding RNAs (lncRNAs) have been shown to be involved in the development and progression of non‑small cell lung cancer (NSCLC). However, the roles of lncRNAs in NSCLC are not well understood. In this study, a high‑throughput microarray was used to compare the lncRNA and mRNA expression profiles in NSCLC and normal tissue (NT) samples. Several candidate adenocarcinoma‑associated ln...

2015
Songwang Cai Zhiqiang Ye Xiaohong Wang Yuhang Pan Yimin Weng Sen Lao Hongbo Wei Lian Li

BACKGROUND P21-activated kinase 4 (PAK4), an effector of the Rho family protein Cdc42, is an important oncogene whose expression is increased in many human cancers and is generally positively correlated with advanced disease and decreased survival. However, little is known about the expression and biological function of PAK4 in human non-small cell lung cancer (NSCLC). METHODS PAK4 expression...

2016
Bin Liang Yang Shao Fei Long Shu-Juan Jiang

Lung cancer is the primary reason for death due to cancer worldwide, and non-small-cell lung cancer (NSCLC) is the most common subtype of lung cancer. Most patients die from complications of NSCLC due to poor diagnosis. In this paper, we aimed to predict gene biomarkers that may be of use for diagnosis of NSCLC by integrating differential gene expression analysis with functional association net...

Journal: :European review for medical and pharmacological sciences 2014
J Li R Shi P Yu

INTRODUCTION Gene expression profiles of peripheral blood monocytes from patients with non-small cell lung cancer (NSCLC) before and after chemotherapy were used to investigate the effect of chemotherapy on gene expression. MATERIALS AND METHODS Microarray dataset GSE39345 was downloaded from Gene Expression Omnibus, including 32 NSCLC samples before chemotherapy, 17 NSCLC samples after chemo...

2017
Shi-Yang Xie Guang Li Chong Han Yang-Yang Yu Nan Li

Non-small-cell lung cancer (NSCLC) is exceptionally deadly because the tumors lack sensitive early-stage diagnostic biomarkers and are resistant to radiation and chemotherapy. Here, we investigated the role and mechanism of Raf kinase inhibitory protein (RKIP) in NSCLC radioresistance. The clinical data showed that the RKIP expression level was generally lower in radioresistant NSCLC tissues th...

2015
Gaurab Chakrabarti

BACKGROUND Advanced non-small cell lung cancer (NSCLC) is an aggressive tumor that is treated with a combination of chemotherapy and radiation if the patient is not a candidate for surgery. Predictive biomarkers for response to radiotherapy are lacking in this patient population, making it a non-tailored therapy regimen with unknown outcome. Twenty to 30 % of NSCLC harbor an activating mutation...

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