نتایج جستجو برای: nsclc

تعداد نتایج: 17801  

Journal: :The European respiratory journal 2017
Jules L Derks Robert Jan van Suylen Erik Thunnissen Michael A den Bakker Harry J Groen Egbert F Smit Ronald A Damhuis Esther C van den Broek Ernst-Jan M Speel Anne-Marie C Dingemans

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell lung carcinoma (NSCLC) chemotherapy regimens. We analysed outcomes of chemotherapy treatments for LCNEC.The Netherlands Cancer Registry and Netherlands Pathology Registry (PALGA) were searched for patients with stage IV chemother...

2018
Shengwen Li Hui Zhao Jianqiang Li Aizheng Zhang Haibin Wang

Long non-coding RNAs (lncRNAs) have been found to be dysregulated in a variety of tumors. The lncRNA-Low Expression in Tumor (LET) is a recently identified lncRNA, but its expression pattern and biological significance in human non-small cell lung cancer (NSCLC) are still largely unknown. In this study, we found that lncRNA-LET was significantly downregulated in human NSCLC lung tissues and cel...

2017
Kailing Wang Shan Shan Zongjun Yang Xia Gu Yuanyuan Wang Chunhong Wang Tao Ren

Non-small-cell lung cancer (NSCLC) is the most common type in lung cancer, a leading cause of cancer-related death worldwide. Our previous study unraveled a pro-cancer function of IL-33 in fueling outgrowth and metastasis of human NSCLC cells. Herein, we determined that interfere with IL-33 activity was an effective strategy for limiting NSCLC tumor growth using a preclinical model with human N...

Journal: :European review for medical and pharmacological sciences 2016
Z-L Zhuang F-M Tian C-L Sun

OBJECTIVE To assess the impact of miR-361-5p expression levels on non-small-cell lung cancer (NSCLC) survival. PATIENTS AND METHODS A total of 183 patients with NSCLC who underwent surgery between October 2007 and April 2010 were included in this study. Expression levels of miR-361-5p were detected by using qRT-PCR. The association of miR-361-5p expression with clinicopathologic characteristi...

2014
Jie Lei Wenhai Li Ye Yang Qiang Lu Na Zhang Guangzhen Bai Daixing Zhong Kai Su Boya Liu Xiaofei Li Yunjie Wang Xiaoping Wang

Thyroid cancer-1 (TC-1), a natively disordered protein, is widely expressed in vertebrates and overexpressed in many kinds of tumors. However, its exact role and regulation mechanism in human non-small cell lung cancer (NSCLC) are still unclear. In the present study, we found that TC-1 is highly expressed in NSCLC and that its aberrant expression is strongly associated with NSCLC cell prolifera...

2017
Shengguang Wang Hua Zhang Jianquan Zhu Chenguang Li Jinfang Zhu Bowen Shi Bin Zhang Changli Wang

PinX1 has been identified as a suppressor of telomerase enzymatic activity. However, the tumour-suppressive roles of PinX1 in different types of human cancers are unclear. PinX1 expression status and its correlation with clinicopathological features in non-small-cell lung cancer (NSCLC) have not been investigated. Accordingly, in this study, we aimed to evaluate the roles of PinX1 in NSCLC. Pin...

Journal: :European review for medical and pharmacological sciences 2017
B Wu X-J Zhang X-G Li L-S Jiang F He

OBJECTIVE Long non-coding RNA NmrA-like family domain containing 1 pseudogene (Loc344887) has been shown to be aberrantly expressed in non-small cell lung cancer (NSCLC). However, the biological function of Loc344887 in NSCLC remains unknown. The present study aimed to explore the prognosis value of Loc344887 in NSCLC patients. PATIENTS AND METHODS Quantitative reverse transcription-polymeras...

2016
Jian Xiao Cheng-Ping Hu Bi-Xiu He Xi Chen Xiao-Xiao Lu Ming-Xuan Xie Wei Li Shu-Ya He Shao-Jin You Qiong Chen

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a known tumor suppressor in non-small cell lung cancer (NSCLC). By performing a systematic review and meta-analysis of the literature, we determined the prognostic value of decreased PTEN expression in patients with NSCLC. We comprehensively and systematically searched through multiple online databases up to May 22, 2016 for NSCL...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Jeffrey A Engelman Pasi A Jänne Craig Mermel Joseph Pearlberg Toru Mukohara Christina Fleet Karen Cichowski Bruce E Johnson Lewis C Cantley

Therapies that target the EGF receptor (EGFR), such as gefitinib (IRESSA), are effective in a subset of patients with advanced non-small cell lung cancer (NSCLC). The differences in intracellular signaling networks between gefitinib-sensitive and -resistant NSCLCs remain poorly understood. In this study, we observe that gefitinib reduces phospho-Akt levels only in NSCLC cell lines in which it i...

2015
Guang Yang Xue-Jiao Wang Li-Jun Huang Yong-An Zhou Feng Tian Jin-Bo Zhao Peng Chen Bo-Ya Liu Miao-Miao Wen Xiao-Fei Li Zhi-Pei Zhang Gergely Szakacs

ATP-binding cassette (ABC) transporters are associated with poor response to chemotherapy, and confer a poor prognosis in various malignancies. However, the association between the expression of the ABC sub-family G member 4 (ABCG4) and prognosis in patients with non-small-cell lung cancer (NSCLC) remains unclear. NSCLC tissue samples (n = 140) and normal lung tissue samples (n = 90) were resec...

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