نتایج جستجو برای: nsclc

تعداد نتایج: 17801  

2016
Ziming Li Jia Huang Hong Yuan Zhiwei Chen Qingquan Luo Shun Lu

Skp2 is a component of the E3 ubiquitin ligase which promotes the ubiquitination-associated degradation of a cyclin-dependent kinase inhibitor, p27, resulting in increases in non-small cell lung cancer (NSCLC) cell growth. We recently showed that down-regulation of Sirtuin deacetylases 2 (SIRT2) in NSCLC increased cancer cell growth through suppressing p27. However, the underlying mechanisms re...

2016
Xi Zhang Jingfen Ji Yu Yang Juan Zhang Liangfang Shen

Radioresistance has been demonstrated to be involved in the poor prognosis of patients with non-small-cell lung cancer (NSCLC). However, the underlying mechanism remains largely unclear. Investigation on special therapeutic targets associated with radioresistance shows promises for the enhancement of clinical radiotherapy effect toward NSCLC. This study aimed to reveal the role of Stathmin1 (ST...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Keiichi Ota Koichi Azuma Akihiko Kawahara Satoshi Hattori Eiji Iwama Junko Tanizaki Taishi Harada Koichiro Matsumoto Koichi Takayama Shinzo Takamori Masayoshi Kage Tomoaki Hoshino Yoichi Nakanishi Isamu Okamoto

PURPOSE Therapies targeted to the immune checkpoint mediated by PD-1 and PD-L1 show antitumor activity in a subset of patients with non-small cell lung cancer (NSCLC). We have now examined PD-L1 expression and its regulation in NSCLC positive for the EML4-ALK fusion gene. EXPERIMENTAL DESIGN The expression of PD-L1 at the protein and mRNA levels in NSCLC cell lines was examined by flow cytome...

2015
Lei Zhang Biao Xu Yong Qiang Hairong Huang Changtian Wang Demin Li Jianjun Qian

Non-small cell lung cancer (NSCLC) accounts for most lung cancer. To develop new therapy required the elucidation of NSCLC pathogenesis. The deubiquitinating enzymes USP 28 has been identified and studied in colon and breast carcinomas. However, the role of USP28 in NSCLC is unknown. The level mRNA or protein level of USP28 were measured by qRT-PCR or immunohistochemistry (IHC). The role of USP...

Journal: :Oncology reports 2011
Jinxia Sun Zhe Lei Reng-Yun Liu Yufeng Lu Zhixiang Zhuang Xiefang Jiang Qian Qian Zeyi Liu Jun Zhao Hong-Tao Zhang

Non-small cell lung cancer (NSCLC) accounts for ~85% of all cases of lung cancer and TGF-ß refractoriness is very common in NSCLC cells. Constitutively decreased TGFBR1 expression, probably leading to TGF-ß resistance in tumors, is emerging as a novel tumor-predisposing phenotype. However, the precise genetic/epigenetic mechanisms underlying the role of TGFBR1 in NSCLC carcinogenesis are still ...

2015
Changyuan Zhang Jie Li Yi Han Jian Jiang

BACKGROUND Recent reports have shown that C-X-C chemokine receptor type 4 (CXCR4) is a candidate oncogene in several types of human tumors, including non-small cell lung cancer (NSCLC). However, the correlation between CXCR4 expression and clinicopathological characteristics of NSCLC remains controversial and has not been emphasized. The aim of this study is to quantitatively evaluate the assoc...

2015
Xiangguang Shi Lei Zhan Can Xiao Zhe Lei Haiping Yang Longqiang Wang Jun Zhao Hong-Tao Zhang

In human cancers, dysregulated expression of LIM-homeobox gene 2 (LHX2) and downregulation of miR-1238 has been reported separately. However, the relationship between them remains unclear. We investigated the functional contribution of miR-1238 to the regulation of LHX2 in non-small cell lung cancer (NSCLC). Here, computational algorithms predicted that the 3'-untranslated region (3'-UTR) of LH...

2014
HAI GONG SHAORONG HAN HUI YAO HUI ZHAO YANMING WANG

The basic helix-loop-helix transcription factor activating enhancer-binding protein (AP)-4 has been found to be involved in tumor biology. However, the role of AP-4 in non-small cell lung cancer (NSCLC) has yet to be elucidated. The present study aimed to investigate the role of AP-4 expression in NSCLC. AP-4 expression as analyzed using quantitative polymerase chain reaction and western blot a...

2016
Yi Han Kang Shi Shi-Jie Zhou Da-Ping Yu Zhi-Dong Liu

The hMLH1 gene plays an essential role in DNA repair. Methylation of the hMLH1 gene is common in many types of cancer and can lead to the loss of hMLH1 expression. However, the association and clinicopathological significance between hMLH1 promoter hypermethylation and non-small-cell lung cancer (NSCLC) is elusive. Here, we investigated the correlation of hMLH1 promoter hypermethylation and NSC...

2017
Lei He Shouzhen Wu Qiang Hao Elhadji M. Dioum Kuo Zhang Cun Zhang Weina Li Wei Zhang Yingqi Zhang Jiming Zhou Zhijun Pang Lijuan Zhao Xiaowen Ma Meng Li Qiuyang Zhang

Functional significance of co-expressed erythropoietin (EPO) and its receptor (EPOR) in non-small cell lung cancer (NSCLC) had been under debate. In this study, co-overexpression of EPO/EPOR was confirmed to be positively associated with poor survival in NSCLC. The serum EPO in 14 of 35 enrolled NSCLC patients were found elevated significantly and decreased to normal level after tumor resection...

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