objective(s): this study aims to determine the effects of ozone therapy on restoring impaired nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced ckd. materials and methods: sprague–dawley rats were fed with 0.75% adenine-containing diet to induce ckd and chronic tubulointerstitial injury. ozone therapy was administered by rectal insufflation. after 4 we...

Tonicity-responsive binding-protein (TonEBP or NFAT5) is a widely expressed transcription factor whose activity is regulated by extracellular tonicity. TonEBP plays a key role in osmoprotection by binding to osmotic response element/TonE elements of genes that counteract the deleterious effects of cell shrinkage. Here, we show that in addition to this "classical" stimulation, TonEBP protects ce...

Objective(s): This study aims to determine the effects of ozone therapy on restoring impaired Nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced CKD. Materials and Methods: Sprague–Dawley rats were fed with 0.75% adenine-containing diet to induce CKD and chronic tubulointerstitial injury. Ozone therapy was administered by rectal insufflation. After 4 we...

The pituitary adenylate cyclase-activating polypeptide (PACAP) is a trophic factor that promotes neuronal survival and neurite outgrowth. However, the signaling pathways and the transcriptional mechanisms involved are not completely elucidated. Our previous studies aimed at characterizing the transcriptome of PACAP-differentiated PC12 cells revealed an increase in the expression of nuclear fact...

We have previously reported the generation of Rassf6 knockout mice using CRISPR/Cas technology. Furthermore, we that RASSF6 is implicated in regulation canonical nuclear factor (NF)-κB signaling pathway and 7,12-dimethylbenz(a)anthracene induced skin inflammation more remarkably than wild-type mice. In this study, investigated role tumorigenesis a two-stage carcinogenesis model initially develo...