This article reviews the principles and methods of nuclear magnetic resonance spectroscopy, and gives examples of applications carried out at our Facility, which illustrate the capabilities of the technique. Handbook of instrumental techniques from CCiTUB Nuclear Magnetic Resonance 1 ChT.4

Pieter Zeeman observed in 1896 the splitting of optical spectral lines in the field of an electromagnet. Since then, the splitting of energy levels proportional to an external magnetic field has been called the "Zeeman effect". The "Zeeman resonance effect" causes magnetic resonances which are classified under radio frequency spectroscopy (rf spectroscopy). In these resonances, the transitions ...

To observe nuclear magnetic resonance, the sample nuclei are first aligned in a strong magnetic field. In this experiment, you will learn the techniques used in a pulsed nuclear magnetic resonance apparatus (a) to perturb the nuclei out of alignment with the field and (b) to measure the small return signal as the misaligned nuclei precess in the field. Because the return signal carries informat...

Great spectral simplification can be obtained by spreading the conventional one-dimensional nuclear magnetic resonance (NMR) spectrum in two independent frequency dimensions. This so-called two-dimensional NMR spectroscopy removes spectral overlap, facilitates spectral assignment, and provides a wealth of additional information. For example, conformational information related to interproton dis...

lipomatosis of the nerve, also known as fibrolipomatous hamartoma, is characterized by the infiltration of the nerve by fibro-fatty tissue. the affected nerve becomes thicker, and it simulates a mass lesion. lipomatosis usually affects the median nerve and lipomatosis of the sciatic nerve is extremely rare. magnetic resonance imaging (mri) is the key to diagnosis, and it is usually pathognomoni...

conclusion these data indicate that while ce-mri will depict more positive results, there are cases in which dwi will show a positive result while ce-mri is negative. we suggest that the combination of these two imaging modalities might yield more positive results in diagnosing acute ms attack giving rise to a more accurate diagnosis. results ce-mri yielded positive results for 61 (87%) patient...

the application of magnetic resonance to diagnostic medical imaging stands as one of the great scientific achievements in the past 50 years. magnetic resonance techniques are easily applied to organs which remain stationary during the imaging procedure, such as the brain and musculoskeletal system. imaging of moving heart structures and circulating blood is considerably more difficult.   clinic...