Recent studies on the fate of labeled dietary purines in the rat have shown t,hat dietary adenine is a precursor of t,he adenine and of the guanine of tissue nucleic acids (l), but that guanine (2), hypoxanthine (3), and xanthine (3) are not utilized for nucleic acid synthesis. Similar experiments have shown that the pyrimidines, uracil, thymine (2), and cytosine (4) are not incorporated into t...

Understanding and optimization of the photophysics fluorescent nucleoside analogues are critical for their applications in probing structure dynamics nucleic acids, studying interactions with ligands biomolecules.

Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundancy of the TLR family encouraged us to seek materials that can neutralize the p...

The distribution of purines and pyrimidines in desoxypentose nucleic acids prepared from a variety of animal and plant sources has been studied. 1. The nucleic acids were prepared from calf thymus, calf kidney, sheep spleen, horse spleen, chicken erythrocyte, turtle erythrocyte, trout sperm, shad testes, sea urchin sperm, wheat germ, and Pneumococcus Type III. 2. Separate hydrolyses were carrie...

Structured RNA molecules are key players in ensuring cellular viability. It is now emerging that, like proteins, the functions of many nucleic acids are dictated by their tertiary folds. At the same time, the number of known crystal structures of nucleic acids is also increasing rapidly. In this context, molecular replacement will become an increasingly useful technique for phasing nucleic acid...

Nucleic acids are involved in the most important processes occurring in living cells and possess an enormous potential for specific interactions with different biopolymers. Specificity of recognition of DNA and RNA species by complementary nucleic acids is unique in the world of biopolymers. A great number of the proteins involved in processes of replication, transcription, and translation are ...

We describe the synthesis of three angelicin derivatives which can be used for labeling nucleic acids with biotin. These compounds were used to label nucleic acids in the presence of lysed cell constituents. The resulting labelled nucleic acids show hybridization to a genus specific probe for E. coli. The relative comparison of sensitivity indicates that a polyamine linker is better than a poly...

Compared to cellular immunotherapy, engineering macrophage-derived EVs which carry nanoparticles, drugs, proteins, nucleic acids etc. can target tumor cells improve biosafety and treatment efficacy.