One of the two major goals of nutrigenomics is to make full use of genomic information to reveal how genetic variations affect nutrients and other food factors and thereby realize tailor-made nutrition (nutrigenetics). The other major goal of nutrigenomics is to comprehensively understand the response of the body to diets and food factors through various 'omics' technologies such as transcripto...

cancer incidence is projected to increase in the future and an effectual preventive strategy is required to face this challenge. alteration of dietary habits is potentially an effective approach for reducing cancer risk. assessment of biological effects of a specific food or bioactive component that is linked to cancer and prediction of individual susceptibility as a function of nutrient-nutrie...

a Institute of Human Nutrition, University of Southampton School of Medicine, Southampton General Hospital, b National Institutes of Health Research, Nutrition Biomedical Research Unit, Southampton Universities NHS Trust, Southampton General Hospital, c Developmental and Cell Biology, University of Southampton School of Biological Sciences, Southampton, UK Published online: April 6, 2011 www.ka...

The low hanging fruit in genetics research has mostly been harvested, and now the work of studying genes as part of systems biology is well underway. Metabolism and nutrition seem to be an ideal complex system in which to apply the knowledge and methods of genetics and genomics. Diet is perhaps the most important environmental factor we are exposed to. Nutritional factors are thought to be the ...

Cancer incidence is projected to increase in the future and an effectual preventive strategy is required to face this challenge. Alteration of dietary habits is potentially an effective approach for reducing cancer risk. Assessment of biological effects of a specific food or bioactive component that is linked to cancer and prediction of individual susceptibility as a function of nutrient-nutrie...

Systems biology has emerged as a critical concept for biological and medical research. Its growing recognition stems from the reality that organisms exist as systems, and the better we understand the interactions in these complex biological networks, the more readily we can develop effective prevention or treatment strategies that comprehensively address health problems. The field of systems bi...

The Lipgene Food-Exchange Model: a tool to enable investigation of four diets distinct in fatty acid composition D. I. Shaw, A. C. Tierney, S. McCarthy, J. Uprichard, S. Vermunt, H. M. Roche and J. A. Lovegrove School of Food Biosciences, University of Reading, RG6 6AP, Nutrigenomics Research Group, School of Medicine, Trinity College Dublin Institute of Molecular Medicine, St James’s Hospital,...

Advances in "omics"-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and "omics"-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study s...