BACKGROUND Recent studies have demonstrated a protective effect of osteocalcin (OCN) on glucose homeostasis and metabolic syndrome. However, its role in vascular function remains unknown. This study investigated the contribution of OCN to the pathogenesis of endothelial dysfunction in the thoracic aorta of apolipoprotein E-deficient (ApoE-KO) mice. METHODS Eight-week-old ApoE-KO mice were giv...

One-counter nets (OCN) consist of a nondeterministic finite control and a single integer counter that cannot be fully tested for zero. They form a natural subclass of both One-Counter Automata, which allow zero-tests and Petri Nets/VASS, which allow multiple such weak counters. The trace inclusion problem has recently been shown to be undecidable for OCN. In this paper, we contrast the complexi...

ATF4 is an osteoblast-enriched transcription factor of the leucine zipper family. We recently identified that vimentin, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin (Ocn) transcription and osteoblast differentiation. Here we show that TGFβ inhibits ATF4-dependent activation of Ocn by up-regulation of vimentin expression. Osteoblasts lacking At...

That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age. Here we show that the presence of OCN is necessary for the beneficial influence of plasma from young...

Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hype...

The 4.62μm absorption band, observed along the line-of-sight towards various young stellar objects, is generally used as a qualitative indicator for energetic processing of interstellar ice mantles. This interpretation is based on the excellent fit with OCN−, which is readily formed by ultraviolet (UV) or ion-irradiation of ices containing H2O, CO and NH3. However, the assignment requires both ...

UNLABELLED Osteocalcin (OCN), a marker of osteoblast activity, has been implicated in the regulation of energy metabolism by the skeleton and thus may affect body fat measures. OBJECTIVE To examine the relationships of OCN to body fat measures and whether they vary according to markers of energy and vitamin D metabolism. DESIGN AND METHODS Data were obtained from 58 obese adolescents aged 1...

One-counter nets (OCN) are Petri nets with exactly one unbounded place. They are equivalent to a subclass of one-counter automata with just a weak test for zero. Unlike many other semantic equivalences, strong and weak simulation preorder are decidable for OCN, but the computational complexity was an open problem. We show that both strong and weak simulation preorder on OCN are PSPACE-complete....

Hydrogen peroxide (H2O2) has been widely used in environmental cleaning, hospital disinfecting and chemical engineering. Compared to the traditional anthraquinone oxidation method, electrocatalytic two-electron oxygen reduction reaction (2e-ORR) produce H2O2 become a promising alternative due its green, safety reliability. However, industrial application is still limited by slow kinetics low se...

The 4.62μm (2164.5 cm) ‘XCN’ band has been detected in the M -band spectra of 34 deeply embedded young stellar objects (YSO’s), observed with high signal-to-noise and high spectral resolution with the VLT-ISAAC spectrometer, providing the first opportunity to study the solid OCN abundance toward a large number of lowmass YSO’s. It is shown unequivocally that at least two components, centred at ...