TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12. Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu-Hakola disease (NHD) with cystic-like lesions of the bone and brain demyelination that lead to fractures and presenile dementia. The mechanisms of this disease are poorly understood....

PURPOSE The authors performed a prospective evaluation of the efficacy of treating ocular cicatricial pemphigoid (OCP) with subconjunctival mitomycin C. DESIGN Unmasked, prospective, internally controlled case series. METHODS Patients were eligible for treatment with subconjunctival mitomycin C under three criteria: (1) significant complications of systemic immunosuppressant therapy; (2) ma...

Harnessing light for energy gives photosynthetic organisms free energy—great, right? Well, like so many free things, too much of a good thing can turn into a bad thing, like a drought-ending rain that turns into a levybreaching flood. The photosynthetic apparatus, beautifully adapted to capture light, can incur serious damage when too much light energy floods in. Given the variability of light ...

PURPOSE To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctival mRNA into an expression vector; map the region to which sera from OCP pat...

Purpose To report a case with corneal perforation, presumably due to ocular cicatricial pemphigoid (OCP) and bacterial concretion derived from lacrimal canaliculitis. Observations A patient with OCP demonstrated adherence of concretion to the cornea of her right eye. She also demonstrated canaliculitis in this eye. We removed a whitish precipitate from the bottom of the corneal ulcer. When we...

In this work, a simple electrochemical immunoassay based on platinum nanoparticles (PtNPs) using open circuit potential (OCP) detection was developed. The detection of human chorionic gonadotropin hormone (hCG) as a model analyte, was demonstrated by direct electrical detection of PtNPs in hydrazine solution using OCP measurement without any application of either potential or current to the sys...

Octacalcium phosphate (OCP) has attracted the interest of researchers looking for new biomaterials due to its excellent biocompatibility and high formability. Furthermore, it was an attraction medical combination products that ions molecule doping ability OCP, which originated distinct crystal structure. Then, as antibacterial bone substitute, Ag-substituted OCP (OCP-Ag) a candidate centerpiece...

OBJECTIVE We aimed to determine the impact of medical therapy for symptom management on insulin resistance, metabolic profiles, and surrogate markers of cardiovascular disease in polycystic ovary syndrome (PCOS), an insulin-resistant pre-diabetes condition. RESEARCH DESIGN AND METHODS One hundred overweight women (BMI >27 kg/m2), average age 31 years, who were nonsmokers, were not pregnant, d...

OBJECTIVE Several tests have been proposed to diagnose patients with Cushing's syndrome (CS). The aims of the study were: i) to evaluate the performance of salivary cortisol (SC) in hypercortisolism and ii) to compare SC with serum cortisol (SeC) and urinary cortisol. DESIGN AND PATIENTS This was a diagnostic study. Twenty-seven patients with untreated Cushing's disease (CD untr), 21 women co...

UNLABELLED To understand early mineralization events, we studied living murine calvarial tissue by Raman spectroscopy using fibroblast growth factor 2 (FGF2)-soaked porous beads. We detected increased levels of a transient phase resembling octacalcium phosphate in sutures undergoing premature suture closure. INTRODUCTION Several calcium phosphates have been postulated as the earliest inorgani...