Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments drugs the ocular posterior segment retina. New formulations technological developments, such as nanotechnology, novel matrices, non-traditional treatment strategies, open perspectives in this field. The aim of mini-review is highlight promising strategies reported current literature based on innov...

gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. the radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive isotope s...

In this work, a peptide for ocular delivery (POD) and human immunodeficiency virus transactivator were conjugated with biodegradable poly(lactic-co-glycolic acid) (PGLA)-polyethylene glycol (PEG)-nanoparticles (NPs) in an attempt to improve ocular drug bioavailability. The NPs were prepared by the solvent displacement method following two different pathways. One involved preparation of PLGA NPs...

the goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. the mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); the prepared nanoparti...