In this paper we present a framework for reliable determination of the lesion load within the corticospinal tract (CST) of multiple sclerosis patients. The basis constitutes a probabilistic fiber tracking approach which checks possible parameter intervals on the fly using an anatomical brain atlas. By exploiting the range of those intervals, the algorithm is able to resolve fiber crossings and ...

Age-related but not artificially induced muscle fiber atrophy has been shown to occur without any decrease in myonuclear number, although these results remain controversial. The present study was carried out to clarify whether age difference affects the degree of decrease in myonuclear number occurring with denervation-induced fiber atrophy. After denervation of 3-wk-old (young) and 4-mo-old (m...

The relationships between muscle capillarization, estimated O2 diffusion distance from capillary to mitochondria, and O2 uptake (VO2) kinetics were studied in 11 young (mean age, 25.9 yr) and 9 old (mean age, 66.0 yr) adults. VO2 kinetics were determined by calculating the time constants (tau) for the phase 2 VO2 adjustment to and recovery from the average of 12 repeats of a 6-min, moderate-int...

We study the 2-D Helmholtz equation in perturbed stratified media, allowing the existence of guided waves. Our assumptions on the perturbing and source terms are not too restrictive. We prove two results. Firstly, we introduce a Sommerfeld-Rellich radiation condition and prove the uniqueness of the solution for the studied equation. Then, by careful asymptotic estimates, we prove the existence ...

In the newspaper printing industry, offset is the dominating printing method and the use of multicolour printing has increased rapidly in newspapers during the last decade. The offset printing process relies on the assumption that an uniform film of ink of right thickness is transferred onto the printing areas. The quality of reproduction of colour images in offset printing is dependent on a nu...

BACKGROUND This study investigates the coverage of adherence to medicine by the UK and US newsprint media. Adherence to medicine is recognised as an important issue facing healthcare professionals and the newsprint media is a key source of health information, however, little is known about newspaper coverage of medication adherence. METHODS A search of the newspaper database Nexis®UK from 200...