Background: The failure of regeneration after spinal cord injury (SCI) has been attributed to axonal demyelination and neuronal death. Cellular replacement and white matter regeneration are both necessary for SCI repair. In this study, we evaluated the co-transplantation of olfactory ensheathing cells (OEC) and embryonic stem (ES) cell-derived motor neurons (ESMN) on contused SCI. Methods: OEC...

background: the failure of regeneration after spinal cord injury (sci) has been attributed to axonal demyelination and neuronal death. cellular replacement and white matter regeneration are both necessary for sci repair. in this study, we evaluated the co-transplantation of olfactory ensheathing cells (oec) and embryonic stem (es) cell-derived motor neurons (esmn) on contused sci. methods: oec ...

multiple sclerosis (ms) causes loss of the myelin sheath, which leads to loss of neurons. regeneration of myelin sheath stimulates axon regeneration and neurons’ survival. in this study, olfactory ensheathing cell (oec) transplantation is investigated to restore myelin sheath in an experimental model of ms in male mice.oecs were isolated from the olfactory mucosa of seven-day-old infant rats an...

Olfactory ensheathing cells (OECs) are found in the olfactory bulb and olfactory nasal mucosa. They resemble Schwann cells on light and electron microscopy, however, immunohistochemical staining can distinguish between the two. There are less than 30 cases of olfactory groove schwannomas reported in the literature while there is only one reported case of OEC tumor. We report an OEC tumor in a 4...

Genome wide transcriptional profiling and large scale proteomics have emerged as two powerful methods to dissect the molecular properties of specific neural tissues or cell types on a global scale. Several genome-wide transcriptional profiling and proteomics studies have been published on cultured olfactory ensheathing cells (OEC). In this article we present a meta-analysis of all five publishe...

Olfactory ensheathing cells (OEC) transplanted to the site of a spinal cord injury can promote axonal sparing/regeneration and functional recovery. The purpose of this study was to investigate if OEC enhance the effects of grafted dopamine-neuron-rich ventral mesencephalic tissue (VM) in a rodent model of Parkinson's disease. We co-grafted VM with either OEC or astrocytes derived from the same ...

The primary olfactory nervous system is unique in that it continuously renews itself and regenerates after injury. These properties are attributed to the presence of olfactory glia, termed olfactory ensheathing cells (OECs). Evidence is now emerging that individual OEC populations exist with distinct anatomical localisations and physiological properties, but their differential roles have not be...

BACKGROUND The failure of regeneration after spinal cord injury (SCI) has been attributed to axonal demyelination and neuronal death. Cellular replacement and white matter regeneration are both necessary for SCI repair. In this study, we evaluated the co-transplantation of olfactory ensheathing cells (OEC) and embryonic stem (ES) cell-derived motor neurons (ESMN) on contused SCI. METHODS OEC ...

Multiple Sclerosis (MS) causes loss of the myelin sheath, which leads to loss of neurons. Regeneration of myelin sheath stimulates axon regeneration and neurons' survival. In this study, olfactory ensheathing cell (OEC) transplantation is investigated to restore myelin sheath in an experimental model of MS in male mice.OECs were isolated from the olfactory mucosa of seven-day-old infant rats an...

background: transplantation approaches are interventions currently available to apply to the devastating problem of spinal cord injury (sci). olfactory ensheathing cell (oec) and embryonic stem cell (esc) are considered to be promising therapeutic strategies . in this study, we compared the potential use of oecs and neurally pre-differentiated escs in contusion spinal cord. methods: oecs were h...