OBJECTIVE To determine the association between the presence of oligohydramnios, determined as an amniotic fluid index ≤ 5 cm and the intra-amniotic inflammatory response, fetal inflammatory response and neonatal outcomes in actively managed preterm prelabor rupture of membranes (PPROM). METHODS Women with singleton pregnancies complicated by PPROM at a gestational age of between 24+0 and 36+6...

BACKGROUND Babies born after midtrimester preterm prelabour rupture of membranes (PPROM) are at risk to develop neonatal pulmonary hypoplasia. Perinatal mortality and morbidity after this complication is high. Oligohydramnios in the midtrimester following PPROM is considered to cause a delay in lung development. Repeated transabdominal amnioinfusion with the objective to alleviate oligohydramni...

OBJECTIVE To examine fetal growth and perinatal outcomes in pregnancies with isolated oligohydramnios. DESIGN A cohort study. SETTING Multiple clinics and hospitals. POPULATION Low risk pregnant women. METHODS We used data from the multicentre clinical trial of Routine Antenatal Diagnostic Imaging with UltraSound (RADIUS), in which 15,151 low risk pregnant women were randomly assigned t...

Oligohydramnios is frequently used to identify at risk fetuses. The purpose of this study was to assess adverse perinatal outcomes in oligohydramnios. Subjects comprised pregnant women diagnosed either with (590) or without (597) oligohydramnios who delivered after hospital admittance from 2000 to 2010 . Data, including the resuscitation of newborn, Apgar score at 5 min, NICU admission, death i...

Oligohydramnios developing early in pregnancy is less common, and the fetal outcomes are usually poor. This is because prolonged decrease in amniotic fluid may cause compression sequences, such as pulmonary hypoplasia, muscle hypotrophy or joint constriction. Early-onset oligohydramnios may be caused by preterm premature rupture of membranes (pPROM) or decreased secretion of amniotic fluid. Ear...

Danshen extract has been used in the treatment of oligohydramnios, however, the mechanism of its action has not been elucidated. Previously, we demonstrated that down-regulation of AQP3 in fetal membranes may contribute to the development of oligohydramnios. In this study, we investigated the effects of Danshen extract on AQP3 expression in human amniotic epithelial cells from term pregnancies ...

Background: Amniotic fluid acts like a cushion and helps in growth of fetus, decrease in amniotic fluid volume may lead to increased risk of intrauterine growth retardation (IUGR), meconium aspiration syndrome, severe birth asphyxia, low APGAR scores and congenital abnormities. Objective: This study was done to see effects of Oligohydramnios on fetal outcome in the form of neonatal morbidity an...

Background: Amniotic fluid acts like a cushion and helps in growth of fetus, decrease in amniotic fluid volume may lead to increased risk of intrauterine growth retardation (IUGR), meconium aspiration syndrome, severe birth asphyxia, low APGAR scores and congenital abnormities. Objective: This study was done to see effects of Oligohydramnios on fetal outcome in the form of neonatal morbidity an...

low-risk pregnancy include evaluation of decreased fetal movement, spontaneous variable decelerations during monitoring to evaluate for labor, or an ultrasound evaluation for fundal height measurements discordant with gestational age. How should “isolated” oligohydramnios—an AFI <5 cm—be interpreted, and should immediate induction be recommended for such patients? Oligohydramnios occurs in abou...

Pulmonary hypoplasia is common in the perinatal period and is a significant cause of death in newborn infants, and oligohydramnios is one of the most commonly associated abnormalities.1 Oligohydramnios may retard fetal lung growth and can result in pulmonary hypoplasia in experimental animals and human fetuses with prolonged rupture of membranes.2,3 Neonates exposed to oligohydramnios caused by...