Tumor hypoxia is strongly associated with an adverse prognosis in cancer, irrespective of treatment modality. Analysis of this association has revealed that hypoxia signalling pathways mediated by hypoxia inducible factor (HIF) are upregulated in cancer, not only by micro-environment hypoxia, but also by diverse oncogenic signal pathways. Pan-genomic analysis of the HIF transcriptional cascade ...

Background: Hepatocellular carcinoma (HCC) is a major type of liver tumor. It represents up to 90% all malignancies. There are currently no reliable tumor markers or imaging technologies that can accurately diagnose early HCC. The use circulating micro-RNAs (miRNAs miR) as potential tool for detection HCC has become an emerging area study. Objectives: This study aimed evaluate the role miR-23b ...

Introduction: The Epstein–Barr virus (EBV) W repeats are transcribed during viral lytic reactivation, a highly oncogenic form of latency known as latency III, and a rare type of latency (Wp-restricted) that is observed in ~15% of endemic Burkitt’s lymphomas. The W repeats encode an EBV protein, EBNA-LP, whose message is produced by splicing out a short (81 nt) and long (2791 nt) intron. We prev...

Small ribonucleic acids (RNAs) are known to regulate gene expression during early development. However, the dynamics of interaction between small RNAs and polysomes during this process is largely unknown. To investigate this phenomenon, 0-1 h and 7-8 h Drosophila melanogaster embryos were fractionated on sucrose density gradients into four fractions based on A254 reading (1) translationally ina...

results researchers have reported that mirnas can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. during the past two decades, numerous studies have shown that mirnas play an essential role in inhibiting hcc via several different pathways. deregulated mirnas may contribute to carcinogenesis, indicating that mirnas can act a...

MicroRNAs (miRNAs) are a class of small non-coding RNAs that mediate gene expression at the posttranscriptional and translational levels and have been demonstrated to be involved in diverse biological functions. Mounting evidence in recent years has shown that miRNAs play key roles in tumorigenesis due to abnormal expression of and mutations in miRNAs. High throughput miRNA expression profiling...

MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human...

Despite their emergence as an important class of noncoding RNAs involved in cancer cell transformation, invasion, and migration, the precise role of microRNAs (miRNAs) in tumorigenesis remains elusive. To gain insights into how miRNAs contribute to primary tumor formation, we conducted an RNA sequencing (RNA-Seq) analysis of Drosophila wing disc epithelial tumors induced by knockdown of a neopl...

Spliceosome mutations are frequently observed in patients with myelodysplastic syndromes (MDS). However, it is largely unknown how these mutations contribute to the disease. MicroRNAs (miRNAs) are small noncoding RNAs, which have been implicated in most human cancers due to their role in post transcriptional gene regulation. The aim of this study was to analyze the impact of spliceosome mutatio...