background : the present study aimed to compare the rates of complete clinical and pathologic response to docetaxel, doxorubicin and cyclophosphamide (tac) vs. 5-fluorouracil, doxorubicin and cyclophosphamide (fac) as neoadjuvant chemotherapy in women with locally advanced breast cancer. methods : one hundred women with pathologically confirmed newly diagnosed locally advanced (t3-t4 or n2-n3) ...

Sample size calculations for trials with time-to-event outcomes are usually based on the assumption that an event – prototypically death in survival analysis occurs only once per sample unit. However, events like changes disease status or switches between treatment modalities may repeat over time. In such outcomes, standard formulae derived from classical time models not applicable. Instead, mo...

Results Overall, the patients were 81% male, 85% Caucasian, with a median age of 36 years. Median baseline CD4 Count was 302 cells/uL, median HIV RNA 4.8 log10 copies/mL. In the primary analysis, 13/79 patients (16.5%) in the ETR arm, versus 36/78 (46.2%) in the EFV arm, showed at least one Grade 1-4 treatmentemergent drug-related NPS AE (p<0.001). The most common nervous system was dizziness, ...

In this paper, a motion planning method based on the Soft Actor-Critic (SAC) is designed for dual-arm robot with two 7-Degree-of-Freedom (7-DOF) arms so that can effectively avoid self-collision and at same time joint limits singularities of arm. The left-arm right-arm each have neural network to control its position orientation. Dual-agent training, distributed training structure, progressive ...