OBJECTIVE One byproduct resulting from free radical damage is the DNA hydroxylation also known as DNA oxidation. Our aim with this work was to determine the relevance of sperm DNA oxidation on embryo quality in oocyte donation cycles. DESIGN We prospectively studied pairs of oocyte donation cycles, i.e., the same oocyte donors, donating to two recipients, where the only difference between the...

BACKGROUND: Mitochondria play vital roles in oocyte functions and they are critical indicators of quality which is important for fertilization development into viable offspring. Quality-compromised oocytes mitochondrial dysfunction plays a significant role correlated with infertility, developmental disorders embryo loss. A the cytoplasmic accumulation sufficient amount pool played by cumulus ce...

Abstract Background The developmental competence of oocyte derived from in vitro maturation (IVM) is significantly lower than those matured vivo. Rapamycin an immunosuppressive substance and widely used to prolong the survival preserve cells culture. objective this research was explore whether rapamycin supplementation during IVM enhances meiotic maturation, quality, subsequent embryonic develo...