In a subset of patients with primary pulmonary hypertension (PPH), high doses of oral calcium-channel blockers (CCB) produce a sustained clinical and haemodynamic improvement. However, significant side-effects have been reported during acute testing with CCB. Therefore, to identify accurately patients who may benefit from long-term CCB therapy, there is a need for a safe, potent and short-actin...

The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target for the development of new mechanism of action diuretics. This idea is supported by the phenotype of antenatal Bartter's syndrome type II associat...

Fiberoptic-compatible oral airways (FCOAs) combine the simplicity and benefits that traditional oral airways provide, with the advantage of mechanically guiding fiberoptic intubation. This review examines and compares the salient properties of these devices. Of note, the clinician should pay particular attention to the location and depth of the channel. FCOAs, with an anterior channel, may be a...

fasting is a religious obligation, which can be challenging for individuals with oral conditions due to its stringent code of conduct. moreover, food abstinence during fasting can restrict oral feeding even further in patients whose nutrition has been already compromised. previous research has mainly concentrated on oral hygiene and gum health, disregarding orodental conditions and diseases. th...

oral malignant melanoma (omm) accounts for 5% of all oral malignancies. it is a rare aggressive neoplasm usually found on the hard palate and gingiva. the etiology is unknown, but tobacco and chronic irritation are suggested as probable causative factors. over 30% of the cases have been reported to arise from pre-existing pigmented lesions. a biopsy is required to establish the diagnosis and th...

background and aims. a correct diagnosis is the most important step in the treatment of oral lesions and each oral lesion has specific clinical features that provide clinical diagnosis; however, some of these features are common among different lesions. in these situations, biopsy and histopathological examination are indicated. the aim of this study was to evaluate the relationship between cli...

introduction the frequency of pediatric and adolescent oral and maxillofacial lesions is various in different societies. the present study aimed at investigating the frequency of oral and maxillofacial pediatric and adolescent biopsies in zahedan (southeast iran), and compare the results with other epidemiologic studies.methods and materials this retrospective study reviewed oral and maxillofac...

This study investigated the impact of oral pushed output on the learning and retention of English perfect tenses. During the study, a pre-test was administered to 22 freshmen majoring in English translation. The participants were randomly assigned to two groups. Then, for six sessions both groups received explicit instructions on English perfect tenses. Every session, the experimental group rec...

Introduction: Ionic channel rearrangements through the demyelinated axons or supporting media play significant role in remission of the neurological deficit in MS patients. In this study the effects of Verapamil as a calcium channel blocker on central conduction have been investigated through the evaluation of changes in P100 latency of the visual evoked potential. Method: This randomized doubl...