This paper proposes a model that considers the action and timing of insulin glucagon in glucose homeostasis after an oral stimulus. We use Bayesian paradigm to infer kinetic rates, namely secretion, gastrointestinal emptying, basal concentration blood. identify two scores related both blood tract. The allow us suggest classification for individuals with impaired sensitivity. </abstra...

BACKGROUND Diagnosis and follow-up of acromegaly is based on measurements of serum growth hormone (GH) concentrations during an oral glucose tolerance test (OGTT). A nadir value <1 microg/L is commonly used to define a normal response, but some authors suggest lower cutoff values. METHODS To compare the results and subsequent patient classification obtained with 3 GH assays, we obtained basal...

OBJECTIVE To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS Six studies (1999-2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C > or =6.5% among diabet...

INTRODUCTION Preanalytical errors still constitute the largest source of errors in laboratory work. Proper patient preparation and patient's knowledge about a particular procedure affects its accuracy and reliability. We hypothesized that most of pregnant women are not well enough informed about the proper procedure for the OGTT. The aims of this study were to investigate: (i) how well pregnant...

OBJECTIVE To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h include...

Several studies have shown that stress has major effects on metabolism. There is also some evidence indicating that stress may induce diabetes mellitus. The present study has investigated the role of chronic psychological stress on carbohydrate metabolism in male Wistar rats (250 ± 50 g). Animals were divided into control and test groups (n = 8/group). Blood samples were obtained by tail snippi...

OBJECTIVE To estimate and report the incidence and perinatal significance of hypoglycemia during the 100-g oral glucose tolerance test in pregnant women. METHODS Over a 3-year period, we analyzed the incidence and perinatal outcome of pregnant women who experienced hypoglycemia, defined as a plasma glucose level of 50 mg/dL or less while undergoing the 100-g oral glucose tolerance test. The s...

Comparison studies between physiological tests are often unsatisfactory for assessing their ability to distinguish between subjects. We recommend a simple but comprehensive protocol, using duplicate testing, that compares tests using 1) the discriminant ratio (DR) between the underlying between- and within-subject SDs, 2) correlation coefficients adjusted for attenuation due to test imprecision...

Objective: To compare efficiency of glucose challenge test with oral glucose tolerance test for detection of gestational diabetes mellitus (GDM). Methods: This observational cross sectional study was conducted in The Department of Obstetrics and Gynaecology, Sharif Medical and Dental College / Sharif Medical City Hospital, from December 2012 to June, 2013. 1000 consecutive pregnant ladies were ...